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Eiwitten en peptiden
Itemnummer:
(PRSI90-220)
Leverancier:
ProSci Inc.
Omschrijving:
Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e. g. platelets) with prothrombin or coagulation factors and inhibits the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the 'annexin V affinity assay' to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.
UOM:
1 * 1 EA
Itemnummer:
(PRSI96-134)
Leverancier:
ProSci Inc.
Omschrijving:
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-377)
Leverancier:
ProSci Inc.
Omschrijving:
Prostatic Acid Phosphatase (PAP) belongs to the histidine acid phosphatase family. PAP can catalyze the hydrolysis of member of phosphate monoestyers, including phosphorylated protein. PAP can high expression in metastasized prostate cancer, moderately expression level in bone diseases, blood cell disease, and the concentration of PAP is used to monitor and assess the proession of prostate cancer. The optimum PH of PAP is from 4 to 6; its activity can be inhibited by L(+)-tartrate.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4105P)
Leverancier:
ProSci Inc.
Omschrijving:
Neurotrypsin peptide is used for blocking the activity of Neurotrypsin antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI40-544)
Leverancier:
ProSci Inc.
Omschrijving:
Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Recombinant human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-988)
Leverancier:
ProSci Inc.
Omschrijving:
WW Domain-Binding Protein 2 (WBP2) is a ubiquitous protein that contains one GRAM domain. The WW domain is composed of 38 to 40 semi-conserved AA shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is participated in mediating protein-protein interactions. WBP2 binds to the WW domain of YAP1, WWP1 and WWP2. The WW-binding 1 motif of WBP2 mediates interaction with NEDD4. The function of this protein WBP2 has not been determined. Some researches demonstrate that WBP-2 also interacts with the thyroid-specific transcription factor Pax8.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-206)
Leverancier:
ProSci Inc.
Omschrijving:
IL-37 (IL-1F7; IL-1H4) belongs to the IL-1 family of proteins. It binds to the interleukin-18 receptor (IL-18R) but not to the IL-1 receptor. It plays an important role as a link between innate and adaptive immunity. IL-37 is a new player in inflammatory and immune responses, mediated by the IL-18/IL-18R axis. It was shown to inhibit tumour growth.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-221)
Leverancier:
ProSci Inc.
Omschrijving:
Tumour necrosis factor (TNF, cachexin or cachectin and formerly known as tumour necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (MultimericTNF-alpha (Prod. No. AG-40B-0019). Since the MultimericTNF-alpha mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha can be used."
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-673)
Leverancier:
ProSci Inc.
Omschrijving:
Proteoglycan 3, also known as Eosinophil major basic protein homolog, Prepro-major basic protein homolog, PRG3 and MBPH, contains one C-type lectin domain. Proteoglycans are a major component of the animal extracellular matrix. PRG3 localizes to the eosinophil secondary granule and is expressed in bone marrow, not detected in placenta. PRG3 has similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, PRG3 can stimulate neutrophil superoxide production and IL8 release, histamine and leukotriene C4 release from basophils.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-678)
Leverancier:
ProSci Inc.
Omschrijving:
High Mobility Group Protein B3 (HMGB3) belongs to the HMGB family. Members of the HMG box subfamily are thought to be have an important role in DNA replication, nucleosome assembly and transcription. HMGB3 binds preferentiallly single-stranded DNA and unwinds double stranded DNA. HMGB3 consists of 200 amino acids and is localized to the cell nucleus. It contains two HMG box DNA-binding domain. HMGB3 binds preferentially single-stranded DNA and unwinds double stranded DNA.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4337P)
Leverancier:
ProSci Inc.
Omschrijving:
Strep-tag II peptide is used for blocking the activity of strep-tag II antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4321P)
Leverancier:
ProSci Inc.
Omschrijving:
CCDC98 peptide is used for blocking the activity of CCDC98 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-255)
Leverancier:
ProSci Inc.
Omschrijving:
alpha-Soluble NSF Attachment Protein (SNAP- alpha) is a member of the SNAP (Soluble NSF Attachment Protein) family. SNAP- alpha interacts with PRKCABP and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. SNAP- alpha is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. SNAP- alpha is in charge of the binding of NSF and therefore the formation of a 20S fusion particle.
UOM:
1 * 50 µG
Itemnummer:
(PRSI40-609)
Leverancier:
ProSci Inc.
Omschrijving:
TNF-alpha is a pleiotrophic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant murine TNF-alpha is a soluble 156 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. Recombinant human TNF-a is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. Recombinant rat TNFTNF-a is a soluble 157 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
UOM:
1 * 50 µG
Itemnummer:
(PRSI40-612)
Leverancier:
ProSci Inc.
Omschrijving:
VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant human VEGF121 is a 28.4 kDa disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.
UOM:
1 * 1 EA
Itemnummer:
(PRSI40-605)
Leverancier:
ProSci Inc.
Omschrijving:
Keratinocyte Growth Factor (KGF/FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of variety of tissues, by promoting cellular proliferation and differentiation. KGF/FG-7 is a mitogen factor specific for epithelial cells and keratinocytes and signals through FGFR 2b. KGF/FGF-7 plays a role in kidney and lung development, angiogenesis, and wound healing. Recombinant human KGF/FGF-7 is an 18.9 kDa protein consisting of 163 amino acid residues.
UOM:
1 * 10 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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