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TLC+EXPLORER
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TLC+EXPLORER
Numéro de catalogue:
(ENZOBMLGR3020010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Chromomycin A3 is a GC-specific DNA ligand which inhibits transcription. It may be used as a fluorescent DNA stain. Antibiotic. Cell permeable fluorescent dye that cann be used with Bisbenzimide H33258 to distinguish chromosomes by their total DNA concentration and their DNA base composition. Does not intercalate. Ex(max): 445 nm; Em(max): 575 nm.
UOM:
1 * 10 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
A selective estrogen receptor modulator (SERM). Displays anti-estrogen action along with anti-androgen action. In clinical use for prevention of postmenopausal osteoporosis. Reduces circulating levels of IL-6 and TNFα. Inhibits prostate carcinogenesis in transgenic rat model. May be useful for the prevention of hormone-related cancers.
Numéro de catalogue:
(ENZOBMLEI3080001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
HSP90 inhibitor
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOALX380011M050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Antibiotic which suppresses nitric oxide (NO) toxicity in pancreatic islet cells. Inhibits protein synthesis by inhibition of elongation factor G at the level of the ribosome.
UOM:
1 * 50 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.
Numéro de catalogue:
(ENZOBMLEI2280010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
AG-494 is a member of the tyrphostin family of tyrosine kinase inhibitors and is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 µM) and EGF-dependent cell growth (IC50=6 µM). It selectively inhibits HER1 (EGF receptor) vs. HER1-2 receptor autophosphorylation (HER1: IC50=1.1 µM; HER1-2: IC50=45 µM). HER1-2 is a chimeric receptor consisting of the external HER1 domain fused to an internal HER2 domain. Blocks CDK2 activation and causescells to arrest at late G1 and during S phase.
UOM:
1 * 10 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.
Numéro de catalogue:
(ENZOBMLP2360025)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Fluorogenic substrate for methionine aminopeptidase 2 (MetAP2) (kcat/Km=1.1 x 10 M-1min-1; Km=310 µM) or aminopeptidase N (Km=377 µM). Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).
UOM:
1 * 25 mg
New Product
Numéro de catalogue:
(40041.)
Fournisseur:
Biotium
Description:
DiSC2(5) (3,3′-Diethylthiadicarbocyanine, iodide) binds to DNA-DNA or PNA-DNA duplexes with a large blue-shift of the absorption spectrum. Binding of the dye to PNA-DNA hybrid, in particular, blue-shifts the dye absorption spectrum by as much as 115 nm, offering a visual method to detect nucleic acid hybridization.
UOM:
1 * 50 mg
Fournisseur:
ENZO LIFE SCIENCES
Description:
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC). Has been used to study the coupling of phosphatidylcholine-specific phospholipase C with sphingomyelinase. Shows antitumor and antiviral activity. Inhibits basement membrane collagen synthesis, which is the last step in the development of a new blood vessel. Inhibits induction of nitric oxide synthases (NOS). Induces apoptosis. It indirectly inhibits phorbol ester stimulated PLD activity.
Numéro de catalogue:
(ENZOBMLEI1550100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.
UOM:
1 * 100 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.
Numéro de catalogue:
(50002.)
Fournisseur:
Biotium
Description:
BAPTA and its derivatives are calcium chelators that are commonly used to form calcium buffers with well-defined calcium concentrations. By injecting the chelators into cells or by incubating cells with the AM ester form of the chelators, one can control the cytosolic calcium concentration, an important means to study the roles of calcium. Key advantages of these calcium chelators include relative insensitivity toward intracellular pH change and fast release of calcium.
UOM:
1 * 1 g
Fournisseur:
ENZO LIFE SCIENCES
Description:
Prostaglandin D2 derived nuclear peroxisome proliferator-activated receptor γ (PPARγ) ligand. Induces apoptosis in a number of cell types including human lung cancer cells, synoviocytes and macrophages. Promotes differentiation of fibroblasts to adipocytes. Antiinflammatory activity. Inhibits angiogenesis. Prevents TNFα induced leptin increase in mice. TRPA1 agonist. Serious doubts as to the biological relevance of this prostaglandin have been raised. Endogenous levels seem to be too low to have any effect as a PPARγ ligand.
Numéro de catalogue:
(ENZOBMLEI2520005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
RG-13022 is a non-phenolic tyrphostin analog, which inhibits the EGF receptor (IC50=5 µM) and PDGF receptor tyrosine kinases, and is long-acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=1 µM) as well as tumor growth in vivo. It inhibits both EGF- and PDGF-stimulated DNA synthesis in human glioma cell lines. RG-13022 is non-phenolic and therefore possesses less antioxidant activity than other tyrphostins.
UOM:
1 * 5 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Potent and selective protein kinase C inhibitor which has been used effectively in platelets, Swiss 3T3 fibroblasts and macrophages. Inhibitory profile: PKC, IC50=0.02µM (inhibits α, ßI, ßII and γ subtypes with similar potency); PKA, IC50=2.0µM; phosphorylase kinase, IC50=0.7µM; insulin, EGF and PDGF receptor tyrosine kinases are not inhibited at concentrations up to 50µM.
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