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Anticorps
Numéro de catalogue:
(ENZOADIAAM118E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Caspase-8/FADD-like ICE (FLICE), is an ~55 kDa cytosolic protein belonging to the Fas/APO-1/CD95 death-inducing signaling complex.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADIAAM227E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Fas/APO-1/CD95 is type I-membrane glycoprotein that is a member of the Tumor necrosis factor receptor (TNF-R) family, which includes TNF-R1, TNF-R2, CD27, CD30, and CD40.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADIOSA450E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The phosphoprotein BVR (Biliverdin Reductase) is an oxireductase which catalyzes the reduction of the gamma-meso bridge of Biliverdin to Bilirubin. BVR is unique among all enzymes characterized to date because BVR has dual pH/dual cofactor requirements. The reductase is highly conserved in its primary structure and molecular properties and uses NADH in the acidic range (peak activity at pH~6.7), whereas NADPH is utilized in the basic range (peak activity at pH ~8.7).
UOM:
1 * 100 µl
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
Numéro de catalogue:
(ENZOADINBA102E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere. There are five forms of APP: APP395, APP563, APP695, APP751, and APP770.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADIOSA400E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cleavage of heme b (Fe-protoporphyrin IX) at the a-methene carbon bridge to form the open tetrapyrrole, biliverdin IXa and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO-1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species, biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway represents the only efficient way of making bilirubin and thereby deterring activation of oxygen by the heme molecule. HO-1 belongs to the heat shock protein family (Hsp32), while HO-2 takes a constitutive form expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process carry out important physiological activities. CO may act as a messenger in the brain and systemic organs stimulating cGMP-production through interactions with the heme-dependent form of guanylate cyclase. Bile pigments display potent antioxidant activity as well as effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity, apparently a result of post translational modifications. In rat, the enzyme also shows a tissue specific developmental pattern. BVR is not inactivated by heat shock, and its preexisting message is not sequestered from translation subsequent to thermal stress. Furthermore, reductase preserves microheterogeneity under thermal stress. BVR expression occurs not only in cells and brain regions that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. Rat cDNA for BVR has been isolated and characterized. The deduced protein contains 3 cysteine residues (Cys73, Cys281, and Cys290) involved in cofactor and substrate binding. Human BVR consists of a substantially longer polypeptide than the rat enzyme (41-42 kDa vs. 33 kDa), but also is dual cofactor and dual pH dependent, requires free SH groups for activity, and displays pI and molecular mass microheterogeneity. The human and rat BVR share some antigenic epitopes and show immunochemical cross reactivity.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADIOSA150D)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Anti-HMOX1 Rabbit Polyclonal Antibody
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOALX210505R100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Anti-ENOS Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
New Product
Numéro de catalogue:
(ENZOALX210365C050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOALX210280R100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
UOM:
1 * 100 µl
New Product
Numéro de catalogue:
(ENZOALX210201C050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOALX210356C050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
α-Actinin-4 is an actin-bundling protein of ~100kDa that is associated with cell motility, endocytosis, and cancer invasion. The α-actinin family comprises two non-muscle isoforms (α-actinin-1 and -4) and two skeletal muscle isoforms (α-actinin-2 and -3), with α-actinin-2 being also expressed in cardiac muscle. While α-actinin-4 is almost ubiquitously expressed, particularly high concentrations are found in glomeruli. On the subcellular level it is associated with actin stress fibers, but in certain cells it also localizes to the nucleus. Mutations in the α-actinin-4 gene cause an autosomal-dominant form of familial focal segmental glomerulosclerosis (FSGS), which is thought to result from a defect in glomerular podocyte function. A point mutation in the α-actinin-4 gene was found to generate an antigenic peptide that is recognized by autologous cytolytic T lymphocytes (CTL) on a human lung carcinoma. α-actinin-4 interacts with a variety of proteins, including the ring finger protein BERP, the PDZ-LIM protein CLP-36, the hemidesmosomal and cell-cell contact protein BP180, and the tight junction protein MAGI-1. Moreover, α-actinin-4 forms a ternary complex with Ca2+/ Calmodulin-dependent protein kinase II and Densin-180, a protein of postsynaptic densities in CNS neurons. Ca2+-dependent association of α-actinin-4 with E3KARP is required for Ca2+-dependent inhibition of the Na+/ H+exchanger 3 (NHE3).
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOALX210205C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Peroxisomes are single membrane organelles which are involved in many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via β-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsums disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal β-oxidation enzymes.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(NOVUFAB5239V)
Fournisseur:
Novus Biologicals
Description:
G-protein coupled receptor family C group 5 member A (GPRC5A), also known as Retinoic acid-induced gene 1 protein (RAIG-1), is a member of the G-protein coupled receptor 3 family.
UOM:
1 * 0,1 mL
New Product
Numéro de catalogue:
(ENZOBMLPW93900001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Mouse, Isotype: IgG1
UOM:
1 * 1 mL
New Product
Numéro de catalogue:
(ENZOBPDABS043291)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Mouse neutrophil gelatinase-associated lipocalin (NGAL; also lipocalin 2, 24p3, SIP24, uterocalin and siderocalin) belongs to the lipocalin family of proteins which bind and transport small lipophilic molecules. Following research showing 24p3 dramatically upregulated in kidney cell cultures infected with SV40, it was subsequently identified as a lipocalin. Unlike human NGAL, mouse NGAL is an acute phase protein upregulated in the liver, but like its mammalian homologues, it is upregulated and secreted by the kidney in response to ischemic or nephrotoxic injury. It is also upregulated in the involuting uterus and mammary gland.
UOM:
1 * 1 mg
New Product
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