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ENZO LIFE SCIENCES
Numéro de catalogue:
(ENZOALX201142C025)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
UOM:
1 * 25 µG
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
Numéro de catalogue:
(ENZOBMLSA2660020)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
UOM:
1 * 20 µl
New Product
Numéro de catalogue:
(ENZOBMLSA3280020)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
UOM:
1 * 20 µl
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Alpha-crystallins, which are part of the small Heat shock family members, are major water-soluble proteins present in the lens of the mammalian eye. Phosphorylation of serine residues which occurs during development and in response to stress, is intimately linked with its function. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation.
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.
Fournisseur:
ENZO LIFE SCIENCES
Description:
The 90 kDa molecular chaperone family includes 90 kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells express inducible Hsp90 alpha and constitutive Hsp90 beta isoforms that are encoded by separate genes. The amino acid sequences of human and yeast Hsp90 alpha are 85% and 90% homologous to those of Hsp90 beta, respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular protein in most cells. Hsp90 functions as part of the cell's powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control by serving as a chaperone for many key signaling molecules including steroid receptors, cell cycle kinases involved in signal transduction, and p53. As many of these client proteins are known oncogenes, Hsp90 inhibitors such as 17-AAG, a geldanamycin analog, have been of benefit in the treatment of many cancers.
Numéro de catalogue:
(ENZOBMLPI1360001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
MMP inhibitor
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOBMLAK5120001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The HDAC2 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human HDAC2 included in the kit. The kit is ideal for chemical library screening for candidate inhibitors or kinetic assay of the enzyme under varying conditions.
UOM:
1 * 1 KIT
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
PARP inhibitor
Numéro de catalogue:
(ENZOBMLAK5440001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The LSD1 Fluorimetric Drug Discovery Kit provides human recombinant LSD1 and all reagents for measuring its activity in a sensitive, real-time fluorescent assay.
UOM:
1 * 1 KIT
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
PKC inhibitor
Numéro de catalogue:
(ENZOBMLEI2300001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
CaM kinase inhibitor
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOBMLEI2680001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
CaM kinase inhibitor
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOBMLP3200001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Insulin receptor substrate
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOBMLP2610001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
This peptide (also known as Woodtide), KKISGRLSPIMTEQ, is derived from transcription factor FKHR with the addition of two lysines to facilitate binding to phosphocellulose membranes. It is a substrate for the DYRK family of kinases.
UOM:
1 * 1 mg
New Product
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