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ENZO LIFE SCIENCES
Numéro de catalogue:
(ENZOADI905185100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. In particular, Bnip3L interacts with and overcomes the suppression of apoptosis mediated by Bcl-2 and Bcl-xL.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905645100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905306100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Members of the TNF superfamily regulate immune responses and induce apoptosis. Two members of this family were identified and designated BAFF and April, respectively. Three receptors for BAFF were identified; these include: BCMA (B-cell maturation protein), TACI, and BAFF-R. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B-Cell development and survival, activate NF-κB and c-jun N-terminal kinase, and are involved in B-Cell associated autoimmune diseases.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905628100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.
UOM:
1 * 100 µl
New Product
Numéro de catalogue:
(ENZOADI905665100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Src homology 2 domain containing (Shc) adaptor protein links growth factor, cytokine, and antigen receptor stimulation to the Ras signaling pathway, and plays a critical role in insulin signaling, tumorigenesis, and hematopoietic cell growth and differentiation. Structurally, Shc is composed of an N-terminal phosphotyrosine binding (PTB) domain, a medial CH1 domain, and a C-terminal SH2 domain. Upon binding to activate cell-surface receptors, Shc is phosphorylated at three tyrosine residues (Tyr239, Tyr240, Tyr317) triggering recognition of Shc by SH2-containing proteins such as Grb2.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
PKC inhibitor
Numéro de catalogue:
(ENZOALX270061G010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
2-tert-Butylhydroquinone
UOM:
1 * 10 g
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Patulin ≥98% (par HPLC)
Numéro de catalogue:
(ENZOALX270069M005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Protein kinase inhibitor
UOM:
1 * 5 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Screen-Well® purinergic and adenosine ligands plate contains 72 CNS receptor ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The purinergic and adenosine ligands plate is 1 plate of the larger neurotransmitter library which contains over 650 ligands.
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Screen-Well® cardiotoxicity library is a focused collection of 130 compounds with defined and diverse cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Screen-Well® serotonergic ligands plate contains 79 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The serotonergic ligands plate is 1 plate of the larger neurotransmitter library which contains over 680 ligands.
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Screen-Well® dopaminergic ligands plate contains 80 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The dopaminergic ligands plate is 1 plate of the larger neurotransmitter library which contains over 650 ligands.
Numéro de catalogue:
(ENZOBMLEI2400100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Deprenyl inhibits apoptosis and displays neuroprotective effects in a variety of in vitro and in vivo systems. In vivo it rescues nigral dopaminergic neurons after systemic MPTP treatment. In vitro it rescues PC12 cells from apoptotic cell death induced by trophic withdrawal. The putative target responsible for the anti-apoptotic effects is glyceraldehyde-3-phosphate dehydrogenase. Deprenyl also inhibits monoamine oxidase-B, which is not involved in its anti-apoptotic mechanism. Parkinson’s disease therapeutic.
UOM:
1 * 100 mg
New Product
Numéro de catalogue:
(ENZOBMLEI2590100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cytochrome P450 inhibitor
UOM:
1 * 100 mg
New Product
Numéro de catalogue:
(ENZOBMLSA2930050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Mouse, Isotype: IgG2a
UOM:
1 * 50 µG
New Product
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