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ProSci Inc.
Numéro de catalogue:
(PRSI28-988)
Fournisseur:
ProSci Inc.
Description:
HMG-box containing protein 1 (HBP1) is a member of the high mobility group (HMG) of chromosomal proteins. It is a sequence-specific HMG transcription factor. Several features of HBP1 suggest an intriguing role as a transcriptional and cell cycle regulator in differentiated cells and it may represent a unique transcriptional repressor with a role in initiation and establishment of cell cycle arrest during differentiation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI42-918)
Fournisseur:
ProSci Inc.
Description:
Anti-CHIT1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-923)
Fournisseur:
ProSci Inc.
Description:
Anti-SLC47A2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-912)
Fournisseur:
ProSci Inc.
Description:
Anti-HP Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-554)
Fournisseur:
ProSci Inc.
Description:
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40 L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controllling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40 L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-551)
Fournisseur:
ProSci Inc.
Description:
Lymphocyte-activation gene 3 (LAG3), also known as CD223, is a type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developed as a cancer drug.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI51-576)
Fournisseur:
ProSci Inc.
Description:
Anti-SIRT1 Mouse Monoclonal Antibody
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI70-829)
Fournisseur:
ProSci Inc.
Description:
Anti-ACTG2 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
Numéro de catalogue:
(PRSI51-590)
Fournisseur:
ProSci Inc.
Description:
Anti-HAMP Mouse Monoclonal Antibody
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI70-848)
Fournisseur:
ProSci Inc.
Description:
Anti-C9 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
Numéro de catalogue:
(PRSI79-142)
Fournisseur:
ProSci Inc.
Description:
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI70-850)
Fournisseur:
ProSci Inc.
Description:
Anti-DNASE1 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
Numéro de catalogue:
(PRSI79-131)
Fournisseur:
ProSci Inc.
Description:
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-128)
Fournisseur:
ProSci Inc.
Description:
CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34. It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-371)
Fournisseur:
ProSci Inc.
Description:
Semaphorin-4A (SEMA4A) belongs to the semaphorin family which contains a Ig-like C2-type domain, a PSI domain and a Sema domain. SEMA4A is expressed from day 10 in the embryo, and low levels are found between days 10-12. SEMA4A is a cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signalling. It plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. SEMA4A promotes phosphorylation of TIMD2, inhibits angiogenesis, and promotes axon growth cone collapse, Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI29-507)
Fournisseur:
ProSci Inc.
Description:
The function remains unknown.
UOM:
1 * 1 EA
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