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ProSci Inc.
Numéro de catalogue:
(PRSI5585)
Fournisseur:
ProSci Inc.
Description:
NANOG Antibody: Expression of NANOG is required for the maintenance of pluripotency in epiblast and embryonic stem (ES) cells as well as for the ability to maintain ES self-renewal independently of LIF/Stat3. The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (also known as Oct-4), another germline-specific transcription factor, and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI26-958)
Fournisseur:
ProSci Inc.
Description:
ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-949)
Fournisseur:
ProSci Inc.
Description:
POLM seems to act as an Ig mutase which is responsible for immunoglobulin (Ig) gene hypermutation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-956)
Fournisseur:
ProSci Inc.
Description:
THYN1 is a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis.This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5997P)
Fournisseur:
ProSci Inc.
Description:
STAU1 peptide is used for blocking the activity of STAU1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6005P)
Fournisseur:
ProSci Inc.
Description:
AXIN1 peptide is used for blocking the activity of AXIN1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI31-212)
Fournisseur:
ProSci Inc.
Description:
LHX2 is a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-559)
Fournisseur:
ProSci Inc.
Description:
Interferon alpha-6 (IFN- alpha6) is a secreted protein which belongs to the alpha/ beta interferon family. IFN- alpha6 is produced by macrophages, expressed at low level, only 1.0% of the average gene in this release. IFN- alpha6 contains interferon alpha, beta and delta domain. IFN- alpha has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4539)
Fournisseur:
ProSci Inc.
Description:
AIFM3 Antibody: Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI25-507)
Fournisseur:
ProSci Inc.
Description:
KCMF1 belongs to the KCMF1 family. It contains 1 C2H2-type zinc finger and 1 ZZ-type zinc finger. It has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-508)
Fournisseur:
ProSci Inc.
Description:
ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-514)
Fournisseur:
ProSci Inc.
Description:
The specific function of KLHL8 is not yet known.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4885P)
Fournisseur:
ProSci Inc.
Description:
MARCH8 peptide is used for blocking the activity of MARCH8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4035P)
Fournisseur:
ProSci Inc.
Description:
DRAM peptide is used for blocking the activity of DRAM antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4543)
Fournisseur:
ProSci Inc.
Description:
IRGM Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa that also includes IRGM2 and IRGM3; this antibody may also recognize these proteins.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-303)
Fournisseur:
ProSci Inc.
Description:
Anti-ATAD5 Goat Polyclonal Antibody
UOM:
1 * 1 EA
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