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ProSci Inc.
Numéro de catalogue:
(PRSI92-718)
Fournisseur:
ProSci Inc.
Description:
Interleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that belongs to the interleukin-1 receptor family. IL-1R1 is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signalling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. It also binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signalling complex. An IL1 receptor accessory protein that can heterodimerise with the Type I receptor in the presence of IL1 alpha or IL1β but not IL1ra, was identified. Recombinant IL1 soluble receptor Type I is a potent antagonist of IL1 action.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI42-488)
Fournisseur:
ProSci Inc.
Description:
Anti-IQGAP1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-640)
Fournisseur:
ProSci Inc.
Description:
Pus1 converts specific uridines to PSI in a number of tRNA substrates. Pus1 acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Pus1 is involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-647)
Fournisseur:
ProSci Inc.
Description:
Pycard is a cytosolic soluble protein that forms insoluble aggregates and enhances etoposide-induced apoptosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-641)
Fournisseur:
ProSci Inc.
Description:
RUNX3 belongs to The RUNX family of transcription factors that are important regulators of linage-specific gene expression in major developmental pathways. Runx3 is highly expressed in developing cranial and dorsal root ganglia (DRGs).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3645)
Fournisseur:
ProSci Inc.
Description:
TLR3 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3859P)
Fournisseur:
ProSci Inc.
Description:
Cyclin O peptide is used for blocking the activity of Cyclin O antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3879P)
Fournisseur:
ProSci Inc.
Description:
TANK peptide is used for blocking the activity of TANK antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI35-398)
Fournisseur:
ProSci Inc.
Description:
Anti-Vaccinia virus Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
UOM:
1 * 1 mL
Numéro de catalogue:
(PRSI3877P)
Fournisseur:
ProSci Inc.
Description:
TANK peptide is used for blocking the activity of TANK antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3865P)
Fournisseur:
ProSci Inc.
Description:
UNG1 peptide is used for blocking the activity of UNG1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4243)
Fournisseur:
ProSci Inc.
Description:
IFN-beta Antibody: Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI25-230)
Fournisseur:
ProSci Inc.
Description:
CNBP is a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-232)
Fournisseur:
ProSci Inc.
Description:
TRIM14 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Four alternatively spliced transcript variants for this gene have been describedThe protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Four alternatively spliced transcript variants for this gene have been described.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-451)
Fournisseur:
ProSci Inc.
Description:
The specific function of MPPE1 is not yet known.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-446)
Fournisseur:
ProSci Inc.
Description:
ARL6IP2 is a multi-pass membrane proteinPotential. It belongs to the GBP family. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis.
UOM:
1 * 50 µG
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