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ProSci Inc.
Numéro de catalogue:
(PRSI92-171)
Fournisseur:
ProSci Inc.
Description:
Fibroblast Growth Factor 17 (FGF17) is a member of the heparin-binding growth factors family that is prominently expressed in the cerebellum and cortex. Proteins of this family possess broad mitogenic and cell survival activities and they are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumour growth, and invasion. FGF17 plays an important role in the regulation of embryonic development and it acts as signalling molecule in the induction and patterning of the embryonic brain. In addition, FGF17 stimulates the proliferation and activation of cells that express FGF receptors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4663P)
Fournisseur:
ProSci Inc.
Description:
BICD1 peptide is used for blocking the activity of BICD1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-776)
Fournisseur:
ProSci Inc.
Description:
KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5815)
Fournisseur:
ProSci Inc.
Description:
FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4341)
Fournisseur:
ProSci Inc.
Description:
TEM7 Antibody: Tumor endothelial marker 7 (TEM7) was identified through serial analysis of gene expression on endothelial cells isolated from human normal and malignant colorectal tissues. Further experiments verified TEM7 was highly expressed in the endothelium of numerous other cancer types including breast, lung and brain tumors. At least four isoforms of TEM7 are known to exist; these include intracellular, secreted, and membrane-bound forms. A homologous protein, TEM7R (also known as PLXDC2), acts as a binding partner to TEM7 and is also abundantly expressed in the endothelium of malignant colorectal cancer but is absent or rare in normal colon mucosa. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4345)
Fournisseur:
ProSci Inc.
Description:
CDNF Antibody: The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI26-789)
Fournisseur:
ProSci Inc.
Description:
The specific function of CCDC38 is not yet known.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6191P)
Fournisseur:
ProSci Inc.
Description:
ZHANGFEI peptide is used for blocking the activity of ZHANGFEI antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-614)
Fournisseur:
ProSci Inc.
Description:
COLEC12 encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that can bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. In addition, these receptors can recognize oxidized phospholipids so they may also participate in removing oxidatively damaged or apoptotic cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5989P)
Fournisseur:
ProSci Inc.
Description:
KPNA5 peptide is used for blocking the activity of KPNA5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5647)
Fournisseur:
ProSci Inc.
Description:
Slc37A2 Antibody: The Slc37 gene family consists of four members which have 10-12 predicted transmembrane domains and belong to the sugar-phosphate transporter superfamily. Recent experiments have demonstrated that Slc37A2 is a macrophage-specific gene selectively expressed in obese white adipose tissue. Its transcript is also expressed in spleen and thymus and the cell lines RAW264.7 and THP-1. Compared to wild-type mice, Slc37A2 mRNA is expressed at nine-fold higher levels in abdominal epididymal fat deposits of ob/ob mice, suggesting that it may be required to limit the contribution of macrophages to the inflammatory state present in obesity. Slc37A2 protein is post-translationally modified with the addition of N-linked glycans and migrates as a heterogeneous species of 50-75kDa.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5623)
Fournisseur:
ProSci Inc.
Description:
LZTR2 Antibody: LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-613)
Fournisseur:
ProSci Inc.
Description:
CBX5 is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-607)
Fournisseur:
ProSci Inc.
Description:
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-045)
Fournisseur:
ProSci Inc.
Description:
ZFP64 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 9 C2H2-type zinc fingers and may be involved in transcriptional regulation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-037)
Fournisseur:
ProSci Inc.
Description:
KLHL3 protein contains a poxvirus and zinc finger domain at the N-terminus and six tandem repeats (kelch repeats) at the C-terminus. At the amino acid level, KLHL3 shares 77% similarity with Drosophila kelch and 89% similarity with Mayven (KLHL2), another human kelch homolog. At least three isoforms are produced and may be the result of alternative promoter usage. The KLHL3 maps within the smallest commonly deleted segment in myeloid leukemias characterized by a deletion of 5q; however, no inactivating mutations of KLHL3 could be detected in malignant myeloid disorders with loss of 5q.
UOM:
1 * 1 EA
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