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Protéines et Peptides
Numéro de catalogue:
(PRSI91-775)
Fournisseur:
ProSci Inc.
Description:
Neuroligin 4, X-Linked (NLGN4X) is a single-pass type I membrane protein that belongs to the type-B carboxylesterase/lipase family. NLGN4X is detected at higher levels in heart and at lower levels in the liver, skeletal muscle, and pancreas. NLGN4X is a putative neuronal cell surface protein involved in cell-cell-interactions. NLGN4X may act as splice site-specific ligands for beta -neurexins. It has been shown that NLGN4X is involved in the formation and remodeling of central nervous system synapses. NLGN4X also interacts with discs, large (Drosophila) homolog 4 (DLG4). Defects in NLGN4X have been associated with autism and Asperger syndrome.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-344)
Fournisseur:
ProSci Inc.
Description:
tumour necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumour necrosis factor receptor) superfamily Characterised by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-347)
Fournisseur:
ProSci Inc.
Description:
TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
UOM:
1 * 2 µG
Numéro de catalogue:
(PRSI90-350)
Fournisseur:
ProSci Inc.
Description:
Poly(ADP-ribose) synthesised after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG hydrolyses poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
UOM:
1 * 2 µG
Numéro de catalogue:
(PRSI90-340)
Fournisseur:
ProSci Inc.
Description:
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signalling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-675)
Fournisseur:
ProSci Inc.
Description:
Human TNFSF14 Protein, also known as LIGHT, belongs to a member of the tumour necrosis factor (TNF) ligand family. It can bind to NFRSF3/LTBR. It is a ligand for TNFRSF14, which is a member of the tumour necrosis factor receptor superfamily, and it is also known as a herpesvirus entry mediator ligand (HVEML). TNFSF14 encodes a protein with a 37 aa cytoplasmic domain, 21aa transmembrane domain and 182 aa extracellular region. The gene is predominantly expressed in the spleen and also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumour lines. TNFSF14 protein was found to probably function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Studies have shown that this protein can prevent tumour necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4759P)
Fournisseur:
ProSci Inc.
Description:
CAPN6 peptide is used for blocking the activity of CAPN6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4761P)
Fournisseur:
ProSci Inc.
Description:
PARL peptide is used for blocking the activity of PARL antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3141P)
Fournisseur:
ProSci Inc.
Description:
TLR4 peptide is used for blocking the activity of TLR4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5361P)
Fournisseur:
ProSci Inc.
Description:
Seasonal H1N1 Nucleocapsid Protein peptide is meant to be used as a positive control in ELISA applications to detect Seasonal Influenza A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5359P)
Fournisseur:
ProSci Inc.
Description:
Swine H1N1 Nonstructural Protein 1 peptide is meant to be used as a positive control in ELISA applications to detect Swine-Origin Influenza A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-481)
Fournisseur:
ProSci Inc.
Description:
Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1 and IL-6 by macrophages.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7155P)
Fournisseur:
ProSci Inc.
Description:
17 amino acids near the center of human CRB2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7179P)
Fournisseur:
ProSci Inc.
Description:
16 amino acids near the carboxy terminus of human TRPV1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7187P)
Fournisseur:
ProSci Inc.
Description:
15 amino acids near the carboxy terminus of human FOXP3.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7185P)
Fournisseur:
ProSci Inc.
Description:
17 amino acids near the amino terminus of human TREM1.
UOM:
1 * 50 µG
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