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Eiwitten en peptiden
Itemnummer:
(PRSI4653P)
Leverancier:
ProSci Inc.
Omschrijving:
Nanos3 peptide is used for blocking the activity of Nanos3 antibody.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-455)
Leverancier:
ProSci Inc.
Omschrijving:
Epidermal growth factor (EGF) is a growth factor and the founding member of the EGF family. All EGF family members are synthesised as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis. EGF is present in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid. Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members. These receptors undergo a complex pattern of ligand induced homo or heterodimerisation to transduce EGF family signals. EGF binds to the receptor EGFR stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity initiates a signal transduction cascade that results in a variety of biochemical changes within the cell, including a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR, which lead to DNA synthesis, cell growth, proliferation and differentiation. Other biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4), also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterised by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.
UOM:
1 * 1 EA
Itemnummer:
(PRSI4707P)
Leverancier:
ProSci Inc.
Omschrijving:
NUP160 peptide is used for blocking the activity of NUP160 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4699P)
Leverancier:
ProSci Inc.
Omschrijving:
NUP107 peptide is used for blocking the activity of NUP107 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6185P)
Leverancier:
ProSci Inc.
Omschrijving:
RBM35A peptide is used for blocking the activity of RBM35A antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-462)
Leverancier:
ProSci Inc.
Omschrijving:
IL-1beta is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1beta belongs to the IL-1 family of proteins that are involved in the inflammatory response. IL-1beta in most situations requires the inflammasome complex to be cleaved and secreted.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-456)
Leverancier:
ProSci Inc.
Omschrijving:
Erythropoietin is the principal hormone involved in the regulation of erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells and the maintenance of a physiological level of circulating erythrocyte mass. It is a glycoprotein produced primarily by the kidney. The biological effects of EPO are mediated by the erythropoietin receptor (Epo R). Genetic variations in EPO is associated with susceptibility to microvascular complications of diabetes type 2 (MVCD2) (including diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease and diabetic neuropathy). It is used for the treatment of anemia and misused as a performance-enhancing drug in endurance athletes.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4595P)
Leverancier:
ProSci Inc.
Omschrijving:
VPS53 peptide is used for blocking the activity of VPS53 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-791)
Leverancier:
ProSci Inc.
Omschrijving:
TINAGL1 is a secreted protein and contains one SMB (somatomedin-B) domain. TINAGL1 is expressed in aorta, lymph nodes, heart, bone marrow, placenta, lung, kidney, skeletal muscle, pancreas, thyroid, adrenal gland and so on. TINAGL1 may be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-359)
Leverancier:
ProSci Inc.
Omschrijving:
EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerisation and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signalling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signalling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably couplling the EGF receptor signalling to the G protein-coupled receptor signalling.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-361)
Leverancier:
ProSci Inc.
Omschrijving:
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumouricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6023P)
Leverancier:
ProSci Inc.
Omschrijving:
MFSD1 peptide is used for blocking the activity of MFSD1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-673)
Leverancier:
ProSci Inc.
Omschrijving:
Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-440)
Leverancier:
ProSci Inc.
Omschrijving:
Ly6/PLAUR domain containing3 (LYPD-3) is a GPI-linked protein. The structure of LYPD-3 is similar to the urokinasetype plasminogen activator receptor (uPAR). LYPD-3 is a 6 -100 kDa molecule with variable cell type-specific N-O-linked glycosylation, mature human LYPD-3 contains two uPAR/Ly6 domains and a Ser/Thr/Pro-rich (STP) region includes a protease sensitive site . The interaction of LYPD-3 with Laminin 1 and 5 on neighboring cells promotes the adhesion, spreading, and migration of tumor cells. LYPD-3 additionally interacts with Galectin-3 and the anterior gradient proteins AG-2 and AG-3. LYPD-3 overexpression in non-small cell lung cancer is predictive of increased mortality.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-771)
Leverancier:
ProSci Inc.
Omschrijving:
Vascular endothelial growth factor A (VEGFA) is also known as Vascular permeability factor (VPF). VEGFA belongs to the PDGF/VEGF growth factor family. VEGFA is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. VEGFA is produced by a group of three major isoforms as a result of alternative splicing and if any three isoforms are produced (VEGFA120, VEGFA164, and VEGFA188) then this will not result in vessel defects and death of the full VEGFA knockout in mice.
UOM:
1 * 20 µG
Itemnummer:
(PRSI3991P)
Leverancier:
ProSci Inc.
Omschrijving:
Blimp-1 peptide is used for blocking the activity of Blimp-1 antibody.
UOM:
1 * 50 µG
Bel voor prijs
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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