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Protéines et Peptides
Numéro de catalogue:
(PRSI3291P)
Fournisseur:
ProSci Inc.
Description:
14 amino acids near the carboxy terminus of human RIP1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3277P)
Fournisseur:
ProSci Inc.
Description:
TLR11 peptide is used for blocking the activity of the TLR11 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3271P)
Fournisseur:
ProSci Inc.
Description:
TLR8 peptide is used for blocking the activity of TLR8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-335)
Fournisseur:
ProSci Inc.
Description:
COL9A1, which is short for Collagen alpha-1(IX) chain, is a 921 aa. protein. It is a secreted protein, and exists in extracellular space and extracellular matrix. This protein is a heterotrimer of an alpha 1(IX), an alpha 2(IX) and an alpha 3(IX) chain.Each subunit is composed of three triple-helical domains interspersed with non-collagenous domains. The globular domain at the N-terminus of type IX collagen molecules represents the NC4 domain which may participate in electrostatic interactions with polyanionic glycosaminoglycans in cartilage. It ia a structural component of hyaline cartilage and vitreous of the eye.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-312)
Fournisseur:
ProSci Inc.
Description:
ApoE, a glycoprotein, is a structural component of very low density lipoprotein (vLDL) Synthesised by the liver and intestinally Synthesised chylomicrons . ApoE is also a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport. ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma. Apolipoprotein E combines with fats (lipids) in the body to form molecules called lipoproteins and Apolipoprotein E is a major component of a specific type of lipoprotein called very low-density lipoproteins (VLDLs).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4419P)
Fournisseur:
ProSci Inc.
Description:
Plxdc2 peptide is used for blocking the activity of Plxdc2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4399P)
Fournisseur:
ProSci Inc.
Description:
ATG10 peptide is used for blocking the activity of ATG10 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-433)
Fournisseur:
ProSci Inc.
Description:
cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. cAMP is a signalling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase A (PKA), which transduces the signal through phosphorylationof different target proteins. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-446)
Fournisseur:
ProSci Inc.
Description:
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterised as a growth factorthat can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by anumber of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cellsand fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophageprogenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. Onmature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on nonhematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF canalso stimulate the proliferation of a number of tumour cell lines, including osteogenic sarcoma, carcinoma andadenocarcinoma cell lines.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-641)
Fournisseur:
ProSci Inc.
Description:
Endothelial cell-specific molecule–1 (ESM-1)—so-called endocan—is a novel endothelium derived soluble dermatan sulphate proteoglycan (PG) that is constitutively expressed by endothelial cells in lungs and kidneys and can be detected in human blood. It is encoded by the ESM1 gene. The expression of this gene is regulated by several cytokines and growth factors, such as vascular endothelial growth factor. Inflammatory cytokines, such as interleukin (IL)-1 beta and tumour necrosis factor (TNF)- alpha, stimulate the upregulation of endocan mRNA and the secretion of endocan from endothelial cells. The binding of circulating endocan to leukocyte ligand for ICAM-1—Lymphocyte Function-associated Antigen-1 (LFA-1) and to leukocyte ligand for VCAM-1—Very Late Antigen-4 (VLA-4) is important in leukocyte adhesion and interaction with activated endothelium. Endocan is a key player in the regulation of major processes such as cell adhesion in inflammatory disorders and tumour progression.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-653)
Fournisseur:
ProSci Inc.
Description:
Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signalling by serving as a co-receptor with LRP-5 for Wnt ligands. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-652)
Fournisseur:
ProSci Inc.
Description:
CD64 (Fc gamma RI), one of the Fc receptors for IgG, is a membrane glycoprotein that mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. CD64 is also structurally distinct, containing an extracellular Ig-interactive region of three Ig-like domains in contrast to the two domains of the low affinity receptors Fc gamma RII and Fc gamma RIII. It is normally expressed on the surfaces of monocytes and macrophages.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6127P)
Fournisseur:
ProSci Inc.
Description:
ZBTB7A peptide is used for blocking the activity of ZBTB7A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6135P)
Fournisseur:
ProSci Inc.
Description:
ZMYM2 peptide is used for blocking the activity of ZMYM2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6161P)
Fournisseur:
ProSci Inc.
Description:
PION peptide is used for blocking the activity of PION antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-397)
Fournisseur:
ProSci Inc.
Description:
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells, platelet aggregation, and cytoskeleton reorganisation. Not only these, it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signalling SOCS1 and SOCS3. In addition, MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE)， deficiency in MERTK are the cause of retinitis pigmentosa.
UOM:
1 * 50 µG
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