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ENZO LIFE SCIENCES
Fournisseur:
ENZO LIFE SCIENCES
Description:
NOS inhibitor
Fournisseur:
ENZO LIFE SCIENCES
Description:
Competitively inhibits the generation of NO from arginine and is a useful tool for inhibition of NO mediated effects. In vitro, L-NMMA inhibits relaxation of rat aorta rings induced by acetylcholine (IC50=9.5µM). In vivo, it causes a dose dependent increase in mean arterial blood pressure in anesthetized rats (EC50=16.7mg/kg).
Numéro de catalogue:
(ENZOALX106012M010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
NOS inhibitor
UOM:
1 * 10 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Glutamate receptor ligand
Fournisseur:
ENZO LIFE SCIENCES
Description:
Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. It delays mouse oocyte maturation and inhibits the growth of a variety of human cell lines including Rhabdomyosarcoma cell line Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts (IC50=18-86µM). It inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes and triggers a G1 arrest similar to interleukin-2 deprivation. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons. N9-Isopropyl-olomoucine and the negative control Iso-olomoucine are also available.
Fournisseur:
ENZO LIFE SCIENCES
Description:
rSec6 and rSec8 are rat homologs of the yeast Sec6 and Sec8 proteins that are essential for protein transport between the Golgi apparatus and the plasma membrane. In yeast, Sec8 is part of a 19.5S complex that includes Sec6 and Sec15, that also associate with the ras-like GTP binding protein Sec4. An analogous 17S complex in rat brain was found to contain rSec6 and rSec8, along with eight proteins with a combined molecular weight of 743 kDa. The membrane-associated rSec6/8 complex co-immunoprecipitates with syntaxin, providing evidence that this complex is involved in synaptic vesicle docking and fusion at the presynaptic terminal.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Membrin, also known as GS27 (Golgi SNARE of 27K), is an integral membrane protein present on the surface of the Golgi apparatus. GS27 is a member of a protein complex that consists of cis-Golgi vesicle receptor syntaxin 5 and GS28, v-SNARE rbet1 and Rsec22, and Rsly1. These complexes are postulated to direct the fusion of ER-derived vesicles with vesicular tubular cluster (VTC), and the fusion of VTCs to form cis-Golgi compartment.
Numéro de catalogue:
(ENZOADIVAMPS001E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Postsynaptic density protein 95 kDa (PSD-95), also known as Synapse associated protein 90 kDa (SAP90), is a brain specific protein that is highly similar to the Drosophila dlg tumor suppressor protein. PSD-95 is a member of membrane associated proteins that are localized beneath the postsynaptic membrane of synapses in the CNS. PSD-95 interacts with NMDA receptor and Shaker-type K+ channels and contributes to their clustering and localization at the synaptic spines in hippocampal neurons and the pinceau terminal of cerebellar basket cells, respectively.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
Fournisseur:
ENZO LIFE SCIENCES
Description:
PARP5a inhibitor
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: IP, WB
Species reactivity:
Numéro de catalogue:
(ENZOENZABS1600100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: Flow Cytometry
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2500100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: IF
Species reactivity: Human, Dog
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: ELISA, IHC, WB
Species reactivity: Human
Numéro de catalogue:
(ENZOENZABS1850100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: IF, IHC (FS)
Species reactivity: Human, Sheep
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2250100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: Flow Cytometry, WB
Species reactivity: Human
UOM:
1 * 1 EA
New Product
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