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ENZO LIFE SCIENCES
Numéro de catalogue:
(ENZOALX201123C500)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
UOM:
1 * 500 µG
New Product
Numéro de catalogue:
(ENZOADI905759100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Glycogen Synthase Kinase 3 (GSK3) exists in two isoforms, alpha and beta (GSK3α, and GSK3β). GSK3 is an active kinase that becomes phosphorylated by PKB/akt upon growth factor stimulation. Phosphorylation of GSK3α at serine 21 or GSK3β at serine 9, respectively, leads to inhibition of kinase activity of the GSK3.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905740100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing GPCR family, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 receptors signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity and modulate cellular potassium and calcium ion channel conductance. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905787100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Bradykinin (BK) is a nine-amino acid peptide produced by kallikrein cleavage of kininogen precursor proteins in tissue and plasma, and is an important regulator of vascular and pain responses to tissue injury. Two receptors (B1 and B2) have been identified as mediators of BK signaling, and are both members of the seven-transmembrane domain-containing G-protein coupled receptor (GPCR) family. The B2 receptor is constitutively expressed in smooth muscle and neurons, whereas B1 expression is induced following tissue injury or during inflammation. The B2 receptor displays high affinity for BK and Lys-BK peptide agonists, while the B1 receptor displays highest affinity to des-Arg9-BK and des-Arg10-kallidin. Both receptors are best characterized as signaling via coupling to Gq alpha subunits (particularly Gq/11), leading to activation of phospholipase C beta, hydrolysis of PI, and an intracellular increase in free calcium, although coupling through Gi, Gs, and G12/13 has also been observed.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905781100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Septin 5 (Sept5/CDCrel-1) is a member of the Septin family of cytoskeletal GTPases. Septin 5 expression is primarily associated with synaptic vesicles in cells of the nervous system where it acts to inhibit exocytosis, although it has also been characterized as an inhibitor of aggregation and release of storage granules in platelets. Phosphorylation of Septin 5 at Ser17 by Cdk5-p35 has been shown to mediate the interaction of Septin 5 with the SNARE protein Syntaxin-1A, regulating neurotransmitter release. Targeted disruption of the Septin 5 gene in mice failed to produce an obvious neurological phenotype, indicating its loss may be overcome by functional redundancy of other septins. Septin 5 is one of several Parkin (an E3 ubiquitin ligase) associated substrates whose accumulation results in cellular toxicity related to the onset of autosomal recessive Parkinson Disease.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Syntaxins are type II integral membrane proteins localized to membranes that regulate vesicle transport, protein maturation, and exocytosis. Syntaxin 1A resides in the nerve terminals of sensory neurons and nerve fibers reaching small blood vessels. Syntaxin 2 localizes to the apical plasma membrane and regulates epithelial-mesenchymal interactions. Syntaxin 6 is primarily localized to the trans-Golgi network, and partially co-localizes with AP-1 on clathrin-coated membranes. Syntaxin 13 is ubiquitously expressed and localizes to the tubular early and recycling endosomes, as well as endosomal vacuoles.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Vesicle-associated membrane protein (VAMP), also known as synaptobrevin, is an 18 kDa integral membrane protein localized to the cytoplasmic surface of synaptic vesicles. Two VAMP homologs, VAMP1 and VAMP2, are differentially expressed in the nervous system. VAMP2 is found in neurons associated with autonomic, sensory and integrative functions, and in non-neuronal Langerhans islets and glomerular cells. VAMP is a component of a 20S complex implicated in vesicle docking and fusion, the formation of which involves the interaction of VAMP with syntaxin through an ATP-dependent reaction modulated by synaptotagmin, SNAP-25, alpha-SNAP, and NSF.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Semisynthetic (from GM1).
Fournisseur:
ENZO LIFE SCIENCES
Description:
Prevents neurotoxicity of glutamate on neuronal cells.
Numéro de catalogue:
(ENZOALX307026M001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
D-myo-Inositol-1-monophosphate dipotassium salt ≥98% (par HPLC)
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOENZABS2980100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: Flow Cytometry
Species reactivity: Species independent
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2960100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: ELISA, ICC, IHC (FS), IHC (PS), WB
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2580100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: ELISA, Flow Cytometry, IP, WB
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2930100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: ELISA, ICC, IHC (FS), IHC (PS), WB
Species reactivity: Human
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
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