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Numéro de catalogue: (ENZOALX270360M005)

Fournisseur:  ENZO LIFE SCIENCES
Description:   Inhibitor of prostaglandin and leukotriene synthesis.
UOM:  1 * 5 mg
New Product
Fournisseur:  ENZO LIFE SCIENCES
Description:   Highly selective and potent inhibitor of cyclooxygenase-2 (IC50=10nM for COX-2 versus IC50=17.8µM for COX-1) with antitumor properties. Exhibits longer half-life time and reduced gastric toxicity in fasting rat model. Has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. Potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.
New Product
Fournisseur:  ENZO LIFE SCIENCES
Description:   SIRT inhibitor
New Product
Fournisseur:  ENZO LIFE SCIENCES
Description:   A potent, cell permeable inhibitor of p38 MAP kinase (IC50=44nM for recombinant purified human p38α). Inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes (IC50=120nM and 350nM, respectively). Reported to protect against mild excitotoxic neuronal injury caused by NMDA and provides substantial protection against cell death induced by either oxygen glucose deprivation (OGD) or magnesium deprivation in cultured neurons. Also, reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of polymorphonuclear (PMN) accumulation.
New Product
Numéro de catalogue: (ENZOALX270316C500)

Fournisseur:  ENZO LIFE SCIENCES
Description:   Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50=6pM).
UOM:  1 * 500 µG
New Product
Numéro de catalogue: (ENZOALX270391M005)

Fournisseur:  ENZO LIFE SCIENCES
Description:   Cell permeable, potent and selective inhibitor of CDK1/cyclin B (IC50=25 nm). Reported to affect the activities of other kinases only at much higher concentrations: PKCα (IC50=6.1 nm), PKA (IC50=125 µm) and EGFR (IC50>10 µm). Induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3 µm).
UOM:  1 * 5 mg
New Product
Fournisseur:  ENZO LIFE SCIENCES
Description:   Anacardic acid ≥95% (par 1H-RMN)
New Product
Numéro de catalogue: (ENZOENZABS2680100)

Fournisseur:  ENZO LIFE SCIENCES
Description:   Recommended Applications: ELISA, IHC

Species reactivity: Human
UOM:  1 * 100 µl
New Product
Fournisseur:  ENZO LIFE SCIENCES
Description:   Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor, which regulates the expression of many detoxification and antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar subfamily of basic leucine zipper (CNC-bZIP) transcription factors. The NF-E2 related family comprises of Nrf1 (TCFII), Nrf2, and Nrf3 and these proteins heterodimerize with Maf proteins to bind to Maf recognition element (MARE). Under normal conditions, Nrf2 is inactive and localized in the cytoplasm through its association with Keap1. When cells are exposed to electrophiles or oxidative stress generating agents cytoplasm localization of Nrf2 is inactivated and Nrf2 translocates into the nucleus and binds to specific DNA sequence elements known as NF-E2 binding site, Maf recognition element (MARE), stress response element or anti-oxidant response element (ARE). Studies have investigated the role of Nrf2 in urinary bladder carcinogenesis, pulmonary fibrosis, and smoke-induced emphysema. A study reported Nrf2-mediated ARE transcription to be a likely target of preventative therapy in neurodegenerative disorders such as Huntington's disease.
New Product
Fournisseur:  ENZO LIFE SCIENCES
Description:   Monomeric G-protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways. Oncogenic mutations, which occur in approximately 30% of all cases of human cancer, lead to the stimulation of proliferation and the inhibition of apoptosis.
New Product
Fournisseur:  ENZO LIFE SCIENCES
Description:   PKA (Protein Kinase A), also known as cAMP-dependent protein kinase, phosphorylates serine or threonine residues in target protein in response to elevated levels of cAMP. Inactive PKA exists as a tetrameric protein composed of two regulatory (R) subunits and two catalytic (C) subunits. Activation occurs when two cAMP molecules bind to each R subunit which causes a conformational change that releases the active C subunits.
New Product
Numéro de catalogue: (ENZOADIKAPPK003E)

Fournisseur:  ENZO LIFE SCIENCES
Description:   Protein Kinase C (PKC) is a large superfamily of serine/threonine kinases that mediate essential cellular signals required for activation, proliferation, differentiation and survival. There are at least ten PKC isotypes that are closely related in structure but that have distinct patterns of tissue distribution and function. The PKC isotypes can be subdivided into three classes based on primary structure and biochemical properties. These are: classical or conventional PKC isotypes (cPKC), novel PKC isotypes (nPKC) and atypical PKC isotypes (aPKC).
UOM:  1 * 1 EA
New Product
Numéro de catalogue: (ENZOENZ339050050)

Fournisseur:  ENZO LIFE SCIENCES
Description:   <i>In situ</i> hybridisation buffer for HPV probes (ready-to use) provides a high quality hybridisation medium for <i>In situ</i> hybridisation analyses using either DNA or oligonucleotide probes labeled with biotin-, or fluorescein-modified nucleotides.
UOM:  1 * 50 mL
New Product
Numéro de catalogue: (ENZOENZ33803)

Fournisseur:  ENZO LIFE SCIENCES
Description:   SignaSure® Wash Buffer is formulated for use with alkaline phosphatase-linked detection reagent assay systems.
UOM:  1 * 3 L
New Product
Numéro de catalogue: (ENZOENZ42505)

Fournisseur:  ENZO LIFE SCIENCES
Description:   Cyanine 3-UTP (Enhanced) can replace UTP as a substrate for T7 RNA polymerase in labeling systems that generate labeled probes through in vitro transcription. Probes generated by these methods are suitable for multicolor fluorescence analysis, specifically dual-color expression arrays in conjunction with cyanine 3-UTP .
UOM:  1 * 250 Nmo
New Product
Numéro de catalogue: (ENZOBMLCA2070005)

Fournisseur:  ENZO LIFE SCIENCES
Description:   Ca²⁺ channel blocker.
UOM:  1 * 5 mg
New Product
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