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ProSci Inc.
Numéro de catalogue:
(PRSI25-055)
Fournisseur:
ProSci Inc.
Description:
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP. This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-044)
Fournisseur:
ProSci Inc.
Description:
The NR2E1 gene is a member of the steroid nuclear receptor superfamily and is predominately expressed in the brain. The contributions of this gene to human B-cell leukemia and to brain development are unknown at present.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-049)
Fournisseur:
ProSci Inc.
Description:
ZNF639 binds DNA and may function as a transcriptional repressor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-668)
Fournisseur:
ProSci Inc.
Description:
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. A1CF has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4805)
Fournisseur:
ProSci Inc.
Description:
Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1 beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4803)
Fournisseur:
ProSci Inc.
Description:
Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1 beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI25-657)
Fournisseur:
ProSci Inc.
Description:
TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-647)
Fournisseur:
ProSci Inc.
Description:
The function of KIAA0427 remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5173P)
Fournisseur:
ProSci Inc.
Description:
PTER peptide is used for blocking the activity of PTER antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5151P)
Fournisseur:
ProSci Inc.
Description:
Siglec11 peptide is used for blocking the activity of Siglec11 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6813P)
Fournisseur:
ProSci Inc.
Description:
ESRRB peptide is used for blocking the activity of ESRRB antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-250)
Fournisseur:
ProSci Inc.
Description:
MEIS3 belongs to the TALE/MEIS homeobox family. It contains 1 homeobox DNA-binding domain. The function of the MEIS3 protein remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-238)
Fournisseur:
ProSci Inc.
Description:
ARGFX belongs to the paired homeobox family.Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain.Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-254)
Fournisseur:
ProSci Inc.
Description:
METT10D belongs to the methyltransferase superfamily, METT10D/rlmF family. The exact function of METT10D remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-242)
Fournisseur:
ProSci Inc.
Description:
ZNF131 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 1 BTB (POZ) domain and 6 C2H2-type zinc fingers. It may be involved in transcriptional regulation. ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6801P)
Fournisseur:
ProSci Inc.
Description:
TFEB peptide is used for blocking the activity of TFEB antibody.
UOM:
1 * 50 µG
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