ProSci Inc.
Numéro de catalogue:
(PRSI61-332)
Fournisseur:
ProSci Inc.
Description:
For WB starting dilution is: 1:16000.
UOM:
1 * 200 µl
New Product
Numéro de catalogue:
(PRSI61-339)
Fournisseur:
ProSci Inc.
Description:
For WB starting dilution is: 1:2000.
UOM:
1 * 200 µl
New Product
Numéro de catalogue:
(PRSI56-393)
Fournisseur:
ProSci Inc.
Description:
SLC12A7 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
UOM:
1 * 400 µl
New Product
Numéro de catalogue:
(PRSI56-400)
Fournisseur:
ProSci Inc.
Description:
PSAPL1 may activate the lysosomal degradation of sphingolipids (By similarity).
UOM:
1 * 400 µl
New Product
Numéro de catalogue:
(PRSI61-336)
Fournisseur:
ProSci Inc.
Description:
For FACS starting dilution is: 1:25. For WB starting dilution is: 1:2000.
UOM:
1 * 200 µl
New Product
Numéro de catalogue:
(PRSI61-333)
Fournisseur:
ProSci Inc.
Description:
For WB starting dilution is: 1:2000.
UOM:
1 * 200 µl
New Product
Numéro de catalogue:
(PRSI56-396)
Fournisseur:
ProSci Inc.
Description:
MEPE seems to play a role in mineralization.
UOM:
1 * 400 µl
New Product
Numéro de catalogue:
(PRSI61-355)
Fournisseur:
ProSci Inc.
Description:
For WB starting dilution is: 1:2000.
UOM:
1 * 200 µl
New Product
Numéro de catalogue:
(PRSI33-641)
Fournisseur:
ProSci Inc.
Description:
Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that CDH16 (kidney-specific cadherin, Cadherin 16) is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, CDH16 is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. CDH16 has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-645)
Fournisseur:
ProSci Inc.
Description:
This mAb reacts with a protein of ~13 kDa, identified as alpha subunit of Luteinizing Hormone (LH) or Chorionic Gonadotrophin (CG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties. LH is synthesised and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-636)
Fournisseur:
ProSci Inc.
Description:
Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesised exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-614)
Fournisseur:
ProSci Inc.
Description:
Recognises a protein of 39 to 45 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-619)
Fournisseur:
ProSci Inc.
Description:
It recognises a protein of 72 kDa, which is identified as MMP2. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP2 (also designated type IV collagenase) cleaves collagen types IV,V, VII and X and gelatin type I. Activation of MMP2 secretion requires the Ras signaling pathway.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-610)
Fournisseur:
ProSci Inc.
Description:
Plakoglobin, also known as junction plakoglobin or gamma Catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin. It is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in Gamma Catenin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.<p>Gamma Catenin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. It links cadherins to the actin cytoskeleton. Gamma Catenin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble desmosomes. [Wiki].
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-633)
Fournisseur:
ProSci Inc.
Description:
This mAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with kappa light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-654)
Fournisseur:
ProSci Inc.
Description:
The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. It is required for normal immune responses. This antibody is specific to the epsilon chain of CD3.
UOM:
1 * 1 EA
New Product
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