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Protéines et Peptides
Numéro de catalogue:
(PRSI96-625)
Fournisseur:
ProSci Inc.
Description:
Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
UOM:
1 * 20 µG
Numéro de catalogue:
(PRSI96-645)
Fournisseur:
ProSci Inc.
Description:
Renin is also known as REN and angiotensinogenase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), and plays an essential role in the elevation of arterial blood pressure and increased sodium retention by the kidney. Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. Renin is secreted from kidney cells, which are activated via signaling from the macula densa, which responds to the rate of fluid flow through the distal tubule, by decreases in renal perfusion pressure (through stretch receptors in the vascular wall), and by sympathetic nervous stimulation, mainly through beta-1 receptor activation. Renin can bind to ATP6AP2, which results in a fourfold increase in the conversion of angiotensinogen to angiotensin I over that shown by soluble renin. In addition, renin binding results in phosphorylation of serine and tyrosine residues of ATP6AP2. The level of renin mRNA appears to be modulated by the binding of HADHB, HuR and CP1 to a regulatory region in the 3' UTR. An over-active renin-angiotension system leads to vasoconstriction and retention of sodium and water. These effects lead to hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6269P)
Fournisseur:
ProSci Inc.
Description:
ApoA4 peptide is used for blocking the activity of ApoA4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6233P)
Fournisseur:
ProSci Inc.
Description:
ZFP281 peptide is used for blocking the activity of ZFP281 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6245P)
Fournisseur:
ProSci Inc.
Description:
LIF peptide is used for blocking the activity of LIF antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6761P)
Fournisseur:
ProSci Inc.
Description:
FOXRED2 peptide is used for blocking the activity of FOXRED2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6753P)
Fournisseur:
ProSci Inc.
Description:
NKX2-8 peptide is used for blocking the activity of NKX2-8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3077P)
Fournisseur:
ProSci Inc.
Description:
PAK4 peptide is used for blocking activity of PAK4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-533)
Fournisseur:
ProSci Inc.
Description:
The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common gamma receptor–like chain (TSLPR- gamma ) and a common interleukin 7 (IL-7) R alpha chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7R alpha chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signalling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-117)
Fournisseur:
ProSci Inc.
Description:
Human recombinant CD55 (from HEK293 cells)
UOM:
1 * 1 EA
Numéro de catalogue:
(BSENPE-1750-1000)
Fournisseur:
Biosensis
Description:
A proprietary preparation of human amyloid beta peptide (amino acids 1-42) that was initially monomerized by HFIP-treatment and then allowed to form oligomers by the procedure described in Youmans KL et al., 2012, followed by lyophilisation using Biosensis’ proprietary stabilization procedures.
The resulting oligomeric mixture has been specially designed to allow the formation of stable, oligomeric Aβ1-42 peptide, multimeric complexes or oligomers. The material is intended to be used as a stable and consistent standard or positive control for oligomeric ELISA assays, as well as other research applications. This product is supplied as 2 x 500 ng vials, each containing lyophilized Aβ oligomers. Note that the amount of provided oligomeric protein is based on the amount of monomeric Aβ used to form these oligomers. The precise formation, size and number of oligomers cannot be quantified by any known method.
UOM:
1 * 1 µG
Numéro de catalogue:
(PRSI96-695)
Fournisseur:
ProSci Inc.
Description:
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-692)
Fournisseur:
ProSci Inc.
Description:
Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327, CD33 antigen-like 1 (CD33L or CD33L1), Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family, which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIGLEC6 mediates sialic-acid dependent binding to cells. SIGLEC6 binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI7077P)
Fournisseur:
ProSci Inc.
Description:
CEBPD Peptide is used for blocking the activity of CEBPD antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-175)
Fournisseur:
ProSci Inc.
Description:
Syntenin-1 is a molecule linking syndecan-mediated signalling to the cytoskeleton. Syntenin-1 is primarily localised to membrane-associated adherens junctions and focal adhesions but also found at the endoplasmic reticulum and nucleus. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. Syntenin-1 may affect cytoskeletal-membrane organisation, cell adhesion, protein trafficking, and the activation of transcription factors. It seems to function as an adapter protein, in adherens junctions may function to couple syndecans to cytoskeletal proteins or signalling components. Syntenin-1 seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) and play a role in vesicular trafficking.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4081P)
Fournisseur:
ProSci Inc.
Description:
BRSK1 peptide is used for blocking the activity of BRSK1 antibody.
UOM:
1 * 50 µG
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