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Protéines et Peptides
Numéro de catalogue:
(PRSI4085P)
Fournisseur:
ProSci Inc.
Description:
BRSK2 peptide is used for blocking the activity of BRSK2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-918)
Fournisseur:
ProSci Inc.
Description:
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-486)
Fournisseur:
ProSci Inc.
Description:
Mouse Programmed cell death 1 ligand 1(Cd274，PD-L1), is a member of the growing B7 family of immune proteins.It involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.B7-H1 has been identified as one of two ligands for programmed death1 (PD1), a member of the CD28 family of immunoreceptors. B7-H1 is constitutively expressed in several organs such as heart, skeletal muscle B7-H1 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. The costimulatory function of B7-H1 is critical for enhancing maturation and differentiation of T-cells in lymphoid organs.B7-H1 expression is also induced in dendritic cells and keratinocytes after IFN gamma stimulation. Interaction of B7-H1 with PD1 results in inhibition of TCR-mediated proliferation and cytokine production. The B7-H1:PD1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-922)
Fournisseur:
ProSci Inc.
Description:
Phosphoinositide-3-kinase-interacting protein 1(PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.It is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. The gene encoding PIK3IP1 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2511P)
Fournisseur:
ProSci Inc.
Description:
NOD2 peptide is used for blocking the activity of NOD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-211)
Fournisseur:
ProSci Inc.
Description:
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerisation and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI92-226)
Fournisseur:
ProSci Inc.
Description:
Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-227)
Fournisseur:
ProSci Inc.
Description:
Mouse CCL9 is a small cytokine belonging to the CC chemokine family. It is expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain. CCL9 can activate osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in bone resorption.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-658)
Fournisseur:
ProSci Inc.
Description:
Protocadherin-1, also known as Cadherin-like protein 1, Protocadherin-42 and PCDH1, belongs to the protocadherin subfamily within the cadherin superfamily. PCDH1 contains seven cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. PCDH1 can be detected as early as embryonic day 9.5. In early embryogenesis, expression is especially prominent in blood vessels. The tight spatial and temporal regulation of Pcdh1 expression suggests that this protocadherin plays multiple roles not only during development but also in mature tissues and organs. In addition, protocadherin-1 is involved in cell-cell interaction processes and in neural cell adhesion.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-770)
Fournisseur:
ProSci Inc.
Description:
Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the relocalization of EPHA2 away from sites of cell-cell contact during transformation. Ephrin-A1 plays an important role in angiogenesis and tumor neovascularization.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-289)
Fournisseur:
ProSci Inc.
Description:
Fatty acid-binding protein 1 (FABP1) is also known as Fatty acid-binding protein, liver (FABPL), Liver-type fatty acid-binding protein (L-FABP). FABP1 / FABPL belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 / L-FABP binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. FABP-1 may be involved in intracellular lipid transport.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI91-901)
Fournisseur:
ProSci Inc.
Description:
Cathepsin E is encoded by the ctse gene, exists in the homodimer forms, belongs to the peptidase A1 family. Cathepsin E high expressed in the stomach, clara cells and alveolar macrophages of lung, brain microglia, spleen and activated B-lymphocytes. Cathepsin E may involve in the processing of antigenic peptides during MHC class II-mediated antigen presentation, play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3647P)
Fournisseur:
ProSci Inc.
Description:
TLR5 peptide is used for blocking the activity of TLR5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7305P)
Fournisseur:
ProSci Inc.
Description:
16 amino acids near the amino terminus of human TIAF.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2157P)
Fournisseur:
ProSci Inc.
Description:
DR6 peptide is used for blocking the activity of DR6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2179P)
Fournisseur:
ProSci Inc.
Description:
DcR1 peptide is used for blocking the activity of DcR1 antibody.
UOM:
1 * 50 µG
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