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Protéines et Peptides
Numéro de catalogue:
(PRSI90-460)
Fournisseur:
ProSci Inc.
Description:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4685P)
Fournisseur:
ProSci Inc.
Description:
Nanos1 peptide is used for blocking the activity of Nanos1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4675P)
Fournisseur:
ProSci Inc.
Description:
BICD2 peptide is used for blocking the activity of BICD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6183P)
Fournisseur:
ProSci Inc.
Description:
VPS39 peptide is used for blocking the activity of VPS39 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-115)
Fournisseur:
ProSci Inc.
Description:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralisation. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-116)
Fournisseur:
ProSci Inc.
Description:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralisation. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4815P)
Fournisseur:
ProSci Inc.
Description:
HINT1 peptide is used for blocking the activity of HINT1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-149)
Fournisseur:
ProSci Inc.
Description:
CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-168)
Fournisseur:
ProSci Inc.
Description:
Contactin-6 is a member of the contactins, which mediate cell surface interactions during nervous system development. Contactin-6 has a key role in the formation of glutamatergic, but not GABAergic, synapses during postnatal development of the hippocampal formation as well as the cerebellum. It is involved in oligodendrocytes generation by acting as a ligand of Notch1. It is also involved in motor coordination.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3807P)
Fournisseur:
ProSci Inc.
Description:
AIM peptide is used for blocking activity of AIM antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2329P)
Fournisseur:
ProSci Inc.
Description:
IKK epsilon peptide is used for blocking the activity of IKK epsilon antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI40-593)
Fournisseur:
ProSci Inc.
Description:
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Recombinant murine GM-CSF (40-617) is a 14.2 kDa globular protein consisting of 124 amino acids residues. Recombinant murine GM-CSF (40-621) is a 14.5 kDa globular protein consisting of 128 amino acids residues.
UOM:
1 * 20 µG
Numéro de catalogue:
(PRSI4297P)
Fournisseur:
ProSci Inc.
Description:
PTK7 peptide is used for blocking the activity of PTK7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4293P)
Fournisseur:
ProSci Inc.
Description:
DISC1 peptide is used for blocking the activity of DISC1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4277P)
Fournisseur:
ProSci Inc.
Description:
ADAP peptide is used for blocking the activity of ADAP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5813P)
Fournisseur:
ProSci Inc.
Description:
FOXO3 peptide is used for blocking the activity of FOXO3 antibody.
UOM:
1 * 50 µG
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