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Protéines et Peptides
Numéro de catalogue:
(PRSI90-511)
Fournisseur:
ProSci Inc.
Description:
Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumours, leading to tumour rejection that is perforin dependent but IFN-gamma independent.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-515)
Fournisseur:
ProSci Inc.
Description:
Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.
UOM:
1 * 25 µG
Numéro de catalogue:
(PRSI5687P)
Fournisseur:
ProSci Inc.
Description:
ADAMTSL5 peptide is used for blocking the activity of ADAMTSL5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI40-514)
Fournisseur:
ProSci Inc.
Description:
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-772)
Fournisseur:
ProSci Inc.
Description:
Brevican Core Protein (BCAN) is a secreted protein that belongs to the aggrecan/versican proteoglycan family. BCAN contains one C-type lectin domain, one EGF-like domain, one Ig-like V-type domain, one Sushi (CCP/SCR) domain and two Link domains. BCAN may play a role in the terminally differentiating and the adult nervous system during postnatal development. BCAN could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-717)
Fournisseur:
ProSci Inc.
Description:
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid beta -protein by neurons and microglia. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF alpha and beta -endorphin.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-209)
Fournisseur:
ProSci Inc.
Description:
Cystatin-5 (CST5) is also known as Cystatin-D, is a secreted thermostable protein, which belongs to the cystatin family. CST5 is a cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B. CST5 / cystatin-D may play a protective role against proteinases present in the oral cavity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-194)
Fournisseur:
ProSci Inc.
Description:
Ciliary neurotrophic factor receptor subunit alpha (CNTFR or CNTFR-alpha) belongs to the type I cytokine receptor family and type 3 subfamily. CNTFR contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. This receptor and its cognate ligand support the survival of neurons. This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3015P)
Fournisseur:
ProSci Inc.
Description:
KLHL1 peptide is used for blocking the activity of KLHL1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-301)
Fournisseur:
ProSci Inc.
Description:
BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6813P)
Fournisseur:
ProSci Inc.
Description:
ESRRB peptide is used for blocking the activity of ESRRB antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6801P)
Fournisseur:
ProSci Inc.
Description:
TFEB peptide is used for blocking the activity of TFEB antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3589P)
Fournisseur:
ProSci Inc.
Description:
Precerebellin peptide is used for blocking the activity of Precerebellin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3569P)
Fournisseur:
ProSci Inc.
Description:
CTRP4 peptide is used for blocking the activity of CTRP4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6925P)
Fournisseur:
ProSci Inc.
Description:
APBA1 peptide is used for blocking the activity of APBA1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5281P)
Fournisseur:
ProSci Inc.
Description:
GALNT10 peptide is used for blocking the activity of GALNT10 antibody.
UOM:
1 * 50 µG
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