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Protéines et Peptides
Numéro de catalogue:
(PRSI91-601)
Fournisseur:
ProSci Inc.
Description:
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. CADM1 may contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, it may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. The protein acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. It may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4087P)
Fournisseur:
ProSci Inc.
Description:
NogoA peptide is used for blocking the activity of NogoA antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4633P)
Fournisseur:
ProSci Inc.
Description:
SAPAP4 peptide is used for blocking the activity of SAPAP4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6103P)
Fournisseur:
ProSci Inc.
Description:
ZIP13 peptide is used for blocking the activity of ZIP13 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6113P)
Fournisseur:
ProSci Inc.
Description:
TFF3 peptide is used for blocking the activity of TFF3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5771P)
Fournisseur:
ProSci Inc.
Description:
SIRT5 peptide is used for blocking the activity of SIRT5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-231)
Fournisseur:
ProSci Inc.
Description:
Heat Shock Protein beta -11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death that correlated with a decreased release of mitochondrial Cytochrome C into the cytosol. Inhibition of HSP90 function completely abrogated the protective effect of HSPB11. This data suggests that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-223)
Fournisseur:
ProSci Inc.
Description:
Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis, as well as in suppressing tumorigenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-232)
Fournisseur:
ProSci Inc.
Description:
Phosphopantothenoylcysteine Decarboxylase (PPC-DC) is an essential enzyme in the biosynthesis ofCoenzyme A and catalyzes the decarboxylation of PPC to Phosphopantetheine. PPC-DC catalyzes the decarboxylation of the Cysteine moiety of 4-Phosphopantothenoylcysteine (PPC) to form 4-Phosphopantetheine (PPantSH), this reaction forms part of the biosynthesis of Coenzyme A. The enzyme is a member of the larger family of Cysteine Decarboxylases including the Lantibiotic-Biosynthesizing enzymes EpiD and MrsD, all of which use a tightly bound Flavin cofactor to oxidize the Thiol moiety of the substrate to a Thioaldehyde.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3917P)
Fournisseur:
ProSci Inc.
Description:
Avian influenza nonstructural protein 2 peptide is used for blocking the activity of avian influenza nonstructural protein 2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3905P)
Fournisseur:
ProSci Inc.
Description:
TRPC3 peptide is used for blocking the activity of TRPC3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3911P)
Fournisseur:
ProSci Inc.
Description:
Avian influenza hemagglutinin 2 peptide is used for blocking activity of avian influenza hemagglutinin 2 antibody. It usually blocks antibody activity completely in ELISA assays by incubating peptide with equal volume of antibody for 30 min at 37 °C antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3963P)
Fournisseur:
ProSci Inc.
Description:
sRANK-L peptide is used for blocking activity of sRANK-L antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-008)
Fournisseur:
ProSci Inc.
Description:
Calcineurin Subunit B Type 1 belongs to the calcineurin regulatory subunit family. Calcineurin Subunit B Type 1 is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase. It is composed of a catalytic subunit (A) and a regulatory subunit (B). It contains four EF-hand domains and four functional calcium-binding sites. Calcineurin Subunit B Type 1 plays an improtant role in the T cell activation pathway.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-420)
Fournisseur:
ProSci Inc.
Description:
Ephrins-A3 belongs the Ephrins ligand family which involved in a variety of biological processes, especially in the nervous system and in erythropoiesis. It is shown that Ephrin-A3 is expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. Ephrin-A3 has a GPI anchor following the extracellular sequence and a signal sequence of 22 amino acids. Ephrin-A3 can bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8 and EphB1. Futhermore, it is associated with tumor growth and metastasis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-427)
Fournisseur:
ProSci Inc.
Description:
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and Neurturin, play key roles in the control of vertebrate neuronal survivial and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF superfamily of growth factors. Three receptors for these factors, GFR alpha-1, GFR alpha-2, and GFR alpha-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFR alpha-1 and GFR alpha-2 have been shown to mediate the GDNF-dependent and Neurturin-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR-3 is expressed only during development. GFR alpha-2 binds Neurturin and mediates activation of RET receptor tyrosine kinase by both Neurturin and GDNF.
UOM:
1 * 50 µG
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