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Protéines et Peptides
Numéro de catalogue:
(PRSI90-085)
Fournisseur:
ProSci Inc.
Description:
Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signalling. It is involved in cell-fate decisions during haematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-071)
Fournisseur:
ProSci Inc.
Description:
The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumour progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-608)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI7017P)
Fournisseur:
ProSci Inc.
Description:
DLK1 peptide is used for blocking the activity of DLK1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7051P)
Fournisseur:
ProSci Inc.
Description:
TNFAIP2 peptide is used for blocking the activity of TNFAIP2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-919)
Fournisseur:
ProSci Inc.
Description:
Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST is asecreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain. It shows sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. SOST is produced by the osteocyte and has anti-anabolic effects on bone formation. It is a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2513P)
Fournisseur:
ProSci Inc.
Description:
NOD2 peptide is used for blocking the activity of NOD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-307)
Fournisseur:
ProSci Inc.
Description:
Flagellin is the subunit protein which polymerises to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) or the intracellular NLRC4 protein. The Flagellin (TLR5 Mutant)(rec. ) cannot be detected by human and mouse TLR5. It has not been tested on NLRC4.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-033)
Fournisseur:
ProSci Inc.
Description:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-649)
Fournisseur:
ProSci Inc.
Description:
Transmembrane Protease Serine 11B (TMPRSS11B) is a single-pass type II membrane protein member of the peptidase S1 family. TMPRSS11B contains one peptidase S1 domain and one SEA domain. TMPRSS11B is a serine protease that may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-759)
Fournisseur:
ProSci Inc.
Description:
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits factors Xa and XIa of the coagulation cascade in the presence of protein Z, calcium, and phospholipid. Mutations in SERPINA10 are associated with venous thrombosis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-763)
Fournisseur:
ProSci Inc.
Description:
Transforming Growth Factor beta -1 (TGF beta -1) is a secreted protein which belongs to the TGF- beta family. TGF beta -1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGF beta -1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGF beta -1 peptide. TGF beta -1 may also form heterodimers with other TGF beta family members. It has been found that TGF beta -1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6091P)
Fournisseur:
ProSci Inc.
Description:
ZIP6 peptide is used for blocking the activity of ZIP6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6089P)
Fournisseur:
ProSci Inc.
Description:
ZIP5 peptide is used for blocking the activity of ZIP5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5775P)
Fournisseur:
ProSci Inc.
Description:
SIRT7 peptide is used for blocking the activity of SIRT7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3925P)
Fournisseur:
ProSci Inc.
Description:
Avian influenza hemagglutinin 2 peptide is used for blocking activity of avian influenza hemagglutinin 2 antibody. It usually blocks antibody activity completely in ELISA assays by incubating peptide with equal volume of antibody for 30 min at 37 °C antibody.
UOM:
1 * 50 µG
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