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Eiwitten en peptiden
Itemnummer:
(PRSI91-482)
Leverancier:
ProSci Inc.
Omschrijving:
Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. In addition, SCARB2 also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-478)
Leverancier:
ProSci Inc.
Omschrijving:
Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-039)
Leverancier:
ProSci Inc.
Omschrijving:
Nuclear Transcription Factor Y Subunit alpha (NFYA) is a member of the NFYA/HAP2 subunit family. NFYA founctions as a heterotrimeric transcription factor , which is composed of three components, NF-YA, NF-YB and NF-YC, binds to CCAAT motifs in the promoter regions in a variety of genes. NFYA forms a highly conserved transcription factor which stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-723)
Leverancier:
ProSci Inc.
Omschrijving:
Uroplakin-2 is a single-pass type I membrane protein that belongs to the uroplakin-2 family. Uroplakin-2 is a component of the asymmetric unit membrane (AUM) and expressed in the ureter, a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. Uroplakin-2 forms heterodimer with UPK1A that is necessary for exiting out of the endoplasmic reticulum (ER). Uroplakin-2 may play an important role in regulating the assembly of the AUM. AUM is believed to strengthen the urothelium by preventing cell rupture during bladder distention.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7379P)
Leverancier:
ProSci Inc.
Omschrijving:
19 amino acids near the center of human B-raf.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7381P)
Leverancier:
ProSci Inc.
Omschrijving:
15 amino acids near the carboxy-terminus of human N-RAS.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7393P)
Leverancier:
ProSci Inc.
Omschrijving:
18 amino acids near the carboxy terminus of human LPIN.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4337P)
Leverancier:
ProSci Inc.
Omschrijving:
Strep-tag II peptide is used for blocking the activity of strep-tag II antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5137P)
Leverancier:
ProSci Inc.
Omschrijving:
FTO peptide is used for blocking the activity of FTO antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5131P)
Leverancier:
ProSci Inc.
Omschrijving:
TNFAIP3 peptide is used for blocking the activity of TNFAIP3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3417P)
Leverancier:
ProSci Inc.
Omschrijving:
Anthrax peptide is used for blocking the activity of Anthrax lethal factor antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3413P)
Leverancier:
ProSci Inc.
Omschrijving:
Anthrax peptide is used for blocking the activity of Anthrax protective antigen antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4453P)
Leverancier:
ProSci Inc.
Omschrijving:
Slitrk1 peptide is used for blocking the activity of Slitrk1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4455P)
Leverancier:
ProSci Inc.
Omschrijving:
Slitrk1 peptide is used for blocking the activity of Slitrk1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-409)
Leverancier:
ProSci Inc.
Omschrijving:
Human CD137 (4-1BB) is a costimulatory molecule of the tumour necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4 + and CD8 + T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumour receptor-associated factors (TRAF), the adaptor protein and mediates downstream signalling events including the activation of NF-kappaB and cytokine production. 4-1BB signalling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumour immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.
UOM:
1 * 1 EA
Itemnummer:
(PRSI92-648)
Leverancier:
ProSci Inc.
Omschrijving:
Follistatin-like 1 (FSTL1) is a secreted glycoprotein that has been grouped into the follistatin family of proteins. FSTL1 is composed of a follistatin domain and two non-functional calcium-binding motifs. It was originally cloned as a TGF beta 1 inducible factor but subsequently shown to regulate diverse developmental pathways and tissue homeostasis. Ablation of the FSTL1 gene in the mouse results in several structural developmental defects and neonatal lethality due to respiratory failure. FSTL1 suppresses BMP signalling, but the precise mechanism of its action has not been elucidated. FSTL1 is expressed in the human placenta, mainly in extra villous trophoblasts.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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