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Eiwitten en peptiden
Itemnummer:
(PRSI92-705)
Leverancier:
ProSci Inc.
Omschrijving:
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition. CEACAM5, also called CEA and CD66e, is characterized by having seven extracellular Ig domains and a glycosylphosphatidylinositol (GPI) anchor. CEACAM5 is expressed primarily by epithelial cells, and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM1. Studies have shown that CEACAM5 is overexpressed in a majority of carcinomas, and its overexpression can protect tumour cells from apoptosis. It is commonly used as a cancer marker.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6517P)
Leverancier:
ProSci Inc.
Omschrijving:
DRGX peptide is used for blocking the activity of DRGX antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6497P)
Leverancier:
ProSci Inc.
Omschrijving:
Strumpellin peptide is used for blocking the activity of Strumpellin antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5119P)
Leverancier:
ProSci Inc.
Omschrijving:
Norrin peptide is used for blocking the activity of Norrin antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5121P)
Leverancier:
ProSci Inc.
Omschrijving:
ZBED2 peptide is used for blocking the activity of ZBED2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5123P)
Leverancier:
ProSci Inc.
Omschrijving:
ZBED3 peptide is used for blocking the activity of ZBED3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4269P)
Leverancier:
ProSci Inc.
Omschrijving:
Carabin peptide is used for blocking the activity of Carabin antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4275P)
Leverancier:
ProSci Inc.
Omschrijving:
MORF4 peptide is used for blocking the activity of MORF4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5795P)
Leverancier:
ProSci Inc.
Omschrijving:
ATG3 peptide is used for blocking the activity of ATG3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5805P)
Leverancier:
ProSci Inc.
Omschrijving:
IFITM1 peptide is used for blocking the activity of IFTIM1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5799P)
Leverancier:
ProSci Inc.
Omschrijving:
ATG13 peptide is used for blocking the activity of ATG13 antibody.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-398)
Leverancier:
ProSci Inc.
Omschrijving:
CD68 is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells and in many tumour cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-608)
Leverancier:
ProSci Inc.
Omschrijving:
Parathyroid hormone 1 receptor(PTH1R) is a multi-pass membrane protein. The protein is expressed in high levels in bone and kidney and regulates calcium ionhomeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. This turns on osteoclasts to ultimately increase the resorption rate.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-609)
Leverancier:
ProSci Inc.
Omschrijving:
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-251)
Leverancier:
ProSci Inc.
Omschrijving:
DCN1-Like Protein 1 is a protein containing 1 DCUN1 domain and 1 UBA-like domain. DCN1-Like Protein 1 contains part of an E3 Ubiquitin Ligase Complex for Neddylation. It is required for Neddylation of Cullin components of E3 Cullin-RING Ubiquitin Ligase complexes. It enhances the rate of Cullins Neddylation. DCN1-Like Protein 1 recruits the NEDD8-charged E2 Enzyme to the Cullin component. DCUN1D1 is involved in the release of inhibitory effects of CAND1 on the Cullin-RING Ligase E3 complex assembly and activity. It acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-573)
Leverancier:
ProSci Inc.
Omschrijving:
Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
UOM:
1 * 50 µG
Bel voor prijs
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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