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Eiwitten en peptiden
Itemnummer:
(PRSI90-013)
Leverancier:
ProSci Inc.
Omschrijving:
CD137 (4-1BB) is a member of the tumour necrosis factor (TNF) receptor family. CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes and cells of blood vessel walls at sites of inflammation. CD137 has costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. CD137 was shown to enhance immune activity to eliminate tumours in mice.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4001P)
Leverancier:
ProSci Inc.
Omschrijving:
APH1 peptide is used for blocking the activity of APH1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-416)
Leverancier:
ProSci Inc.
Omschrijving:
CD152 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulphide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-408)
Leverancier:
ProSci Inc.
Omschrijving:
CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumour necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells.
UOM:
1 * 25 µG
Itemnummer:
(PRSI96-765)
Leverancier:
ProSci Inc.
Omschrijving:
Vasorin (VASN),a single-pass type I membrane protein, is also known as protein slit-like 2 and SLITL2, which contains one EGF-like domain, ten LRR (leucine-rich) repeats, one LRRCT domain and one LRRNT domain. VASN is expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. VASN can interact selectively and non-covalently with TGF-beta, transform growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. In general, VASN may act as an inhibitor of TGF-beta signaling.
UOM:
1 * 1 EA
Itemnummer:
(PRSI5873P)
Leverancier:
ProSci Inc.
Omschrijving:
CRISP2 peptide is used for blocking the activity of CRISP2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5865P)
Leverancier:
ProSci Inc.
Omschrijving:
CCDC106 peptide is used for blocking the activity of CCDC106 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-170)
Leverancier:
ProSci Inc.
Omschrijving:
DLK2 regulates adipogenesis.
UOM:
1 * 1 EA
Itemnummer:
(PRSI40-589)
Leverancier:
ProSci Inc.
Omschrijving:
FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues. Recombinant murine FGF-basic is a 16.2 kDa protein consisting of 145 amino acid residues.
UOM:
1 * 50 µG
Itemnummer:
(PRSI40-518)
Leverancier:
ProSci Inc.
Omschrijving:
Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-β1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-β1 (HRG1-β1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-β1 (65 amino acid residues).
UOM:
1 * 50 µG
Itemnummer:
(PRSI40-521)
Leverancier:
ProSci Inc.
Omschrijving:
Human IL-17A is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.
UOM:
1 * 25 µG
Itemnummer:
(PRSI3809P)
Leverancier:
ProSci Inc.
Omschrijving:
TIM-1 peptide is used for blocking activity of TIM-1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5389P)
Leverancier:
ProSci Inc.
Omschrijving:
RIPK1 peptide is used for blocking the activity of RIPK1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5385P)
Leverancier:
ProSci Inc.
Omschrijving:
JMJD7 peptide is used for blocking the activity of JMJD7 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4803P)
Leverancier:
ProSci Inc.
Omschrijving:
Akirin2 peptide is used for blocking the activity of Akirin2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6861P)
Leverancier:
ProSci Inc.
Omschrijving:
ZNF687 peptide is used for blocking the activity of ZNF687 antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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