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Eiwitten en peptiden
Itemnummer:
(PRSI90-470)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-076)
Leverancier:
ProSci Inc.
Omschrijving:
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
UOM:
1 * 1 EA
Itemnummer:
(PRSI96-615)
Leverancier:
ProSci Inc.
Omschrijving:
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
UOM:
1 * 1 EA
Itemnummer:
(PRSI92-456)
Leverancier:
ProSci Inc.
Omschrijving:
TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2081P)
Leverancier:
ProSci Inc.
Omschrijving:
ARC peptide is used for blocking the activity of ARC antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2091P)
Leverancier:
ProSci Inc.
Omschrijving:
CIDE-A peptide is used for blocking the activity of mCIDE-B antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4247P)
Leverancier:
ProSci Inc.
Omschrijving:
IEX-1 peptide is used for blocking the activity of IEX-1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4265P)
Leverancier:
ProSci Inc.
Omschrijving:
FEZ1 peptide is used for blocking the activity of FEZ1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4251P)
Leverancier:
ProSci Inc.
Omschrijving:
SLPI peptide is used for blocking the activity of SLPI antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6455P)
Leverancier:
ProSci Inc.
Omschrijving:
DBX1 peptide is used for blocking the activity of DBX1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6435P)
Leverancier:
ProSci Inc.
Omschrijving:
TMEM59L peptide is used for blocking the activity of TMEM59L antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-190)
Leverancier:
ProSci Inc.
Omschrijving:
beta -Ureidopropionase is a cytoplasmic protein which belongs to the CN hydrolase family of BUP subfamily. beta -Ureidopropionase binds one zinc ion per subunit, catalyzes the last step in the pyrimidine degradation pathway. beta -Ureidopropionase can convert N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide, respectively. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta aminoisobutyric acid, respectively. Defects in beta -Ureidopropionase are the cause of beta -Ureidopropionase deficiency that is characterized by muscular hypotonia, dystonic movements, scoliosis, microcephaly and severe developmental delay.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-546)
Leverancier:
ProSci Inc.
Omschrijving:
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-430)
Leverancier:
ProSci Inc.
Omschrijving:
Inducible Co-Stimulator Ligand (ICOSLG) belongs to the immunoglobulin superfamily. ICOSLG contains Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. ICOSLG acts as a costimulatory signal for T-cell proliferation and cytokine secretion, it also induces B-cell proliferation and differentiation into plasma cells. It could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. ICOSLG is widely expressed lymph nodes, leukocytes and spleen, detected on activated monocytes and dendritic cells.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-435)
Leverancier:
ProSci Inc.
Omschrijving:
Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays a role in angiogensis and tumorigenesis.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-423)
Leverancier:
ProSci Inc.
Omschrijving:
BTLA is a type I transmembrane glycoprotein of the CD28 family of T cell costimulatory molecules. BTLA functions as a coinhibitor on activated T cells and on B cells and dendritic cells. The extracellular domain (ECD) of this Ig superfamily protein contains one V-type Ig-like domain, which interacts with HVEM.
UOM:
1 * 1 EA
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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