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ProSci Inc.
Numéro de catalogue:
(PRSI33-833)
Fournisseur:
ProSci Inc.
Description:
This mAb recognises basic (Type II or HMW) cytokeratins, which include 67 kDa (CK1); 64 kDa (CK3); 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50 , 48, 46, 45, and 40 kDa. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-843)
Fournisseur:
ProSci Inc.
Description:
Factor XIIIa has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti-Factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases are positive), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma (-). Anti-Factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-781)
Fournisseur:
ProSci Inc.
Description:
S100A4/FSP1 (Fibroblast specific protein 1) belongs to the S100 super-family of proteins containing 2 EF-hand calcium-binding domains. S100 genes include at least 25 members, including S100A1-S100A18, trichohyalin, filaggrin, repetin, S100P, and S100Z. S100A4 exerts its function via direct interaction with a number of proteins including p53, p63, non-muscle myosin IIA, alpha6beta4 integrin, and liprin b1. S100A4 is overexpressed in highly metastatic cancers, which makes it useful as a marker of tumor progression.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-788)
Fournisseur:
ProSci Inc.
Description:
This mAb recognises an ~170 kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-780)
Fournisseur:
ProSci Inc.
Description:
S100A4/FSP1 (Fibroblast specific protein 1) belongs to the S100 super-family of proteins containing 2 EF-hand calcium-binding domains. S100 genes include at least 25 members, including S100A1-S100A18, trichohyalin, filaggrin, repetin, S100P, and S100Z. FSP1 exerts its function via direct interaction with a number of proteins including p53, p63, non-muscle myosin IIA, alpha6beta4 integrin, and liprin b1. FSP1 is overexpressed in highly metastatic cancers, which makes it useful as a marker of tumor progression.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-809)
Fournisseur:
ProSci Inc.
Description:
Epithelial cellular adhesion molecule (EpCAM), is also identified as epithelial specific antigen (ESA) and the 40 kDa transmembrane epithelial glycoprotein EGP40. EpCAM is expressed on the baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. The VU-1D9 antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. EpCAM antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-789)
Fournisseur:
ProSci Inc.
Description:
This mAb recognises an ~170 kDa protein which is identified as Topoisomerase IIa, and shows no cross-reaction with Topoisomerase IIb or I. Topo IIa plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topo IIa is also implicated in drug resistance of tumor cells.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-831)
Fournisseur:
ProSci Inc.
Description:
This mAb reacts with a carbohydrate determinant, identified as CDw78 (Workshop V; Code CDw78.2). The epitope recognized by this mAb and Leu21 is the same. It is present on some immature and some peripheral blood B cells, and some B cell lines. Its expression is increased after B-cell activation in vitro. CDw78 is also found on tissue macrophages and on epithelial cells, but not on T cells, NK cells, monocytes, granulocytes and myeloid tissues. It appears that CDw78 is a determinant on a major histocompatibility complex (MHC) class II subpopulation.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-817)
Fournisseur:
ProSci Inc.
Description:
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94,4% vs. 94,7%.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-842)
Fournisseur:
ProSci Inc.
Description:
This mAb recognises a protein of about 50 kDa which is identified as gamma-Enolase/Neuron Specific Enolase/Enolase 2. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue and gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI33-812)
Fournisseur:
ProSci Inc.
Description:
Recognises a protein of 75 kDa, identified as gamma heavy chain of human immunoglobulins. It reacts with all sub-classes of gamma chain of human immunoglobulins. It does not cross-react with alpha (IgA), mu (IgM), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. This mAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI77-197)
Fournisseur:
ProSci Inc.
Description:
Anti-H2-Ab1 Rat Monoclonal Antibody [clone: M5/114.15.2] (PE (Phycoerythrin))
UOM:
1 * 0,2 mg
New Product
Numéro de catalogue:
(PRSI77-205)
Fournisseur:
ProSci Inc.
Description:
The JES6-5H4 antibody specifically binds to mouse IL-2, a 17 kDa immunoregulatory cytokine and growth factor for T and B lymphocytes, NK cells, monocytes, and macrophages. IL-2 induces the cytotoxic operations of NK cells, activates B cells, and plays a role in the differentiation of T cells. JES6-5H4 seems to have a neutralizing effect on interleukin-2.
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI77-204)
Fournisseur:
ProSci Inc.
Description:
The JES6-5H4 antibody specifically binds to mouse IL-2, a 17 kDa immunoregulatory cytokine and growth factor for T and B lymphocytes, NK cells, monocytes, and macrophages. IL-2 induces the cytotoxic operations of NK cells, activates B cells, and plays a role in the differentiation of T cells. JES6-5H4 seems to have a neutralizing effect on interleukin-2.
UOM:
1 * 0,025 mg
New Product
Numéro de catalogue:
(PRSI93-301)
Fournisseur:
ProSci Inc.
Description:
Anti-Nucleocapsid Phosphoprotein Recombinant Monoclonal Antibody [clone: 4A6]
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI14-964)
Fournisseur:
ProSci Inc.
Description:
Anti-NFS1 Rabbit Polyclonal Antibody
UOM:
1 * 50 µl
New Product
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