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Protéines et Peptides
Numéro de catalogue:
(PRSI3206P)
Fournisseur:
ProSci Inc.
Description:
TIRP peptide is used for blocking the activity of TIRP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4969P)
Fournisseur:
ProSci Inc.
Description:
TREX1 peptide is used for blocking the activity of TREX1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-345)
Fournisseur:
ProSci Inc.
Description:
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMP-2 is ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, atherosclerotic plaque rupture, as well as degrading extracellular matrix proteins. MMP-2 can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. MMP-2 cleaves KISS at a Gly-|-Leu bond and appears to have a role in myocardial cell death pathways.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5251P)
Fournisseur:
ProSci Inc.
Description:
HAAO peptide is used for blocking the activity of HAAO antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-332)
Fournisseur:
ProSci Inc.
Description:
DLL3 (Delta-like protein 3; Delta3) inhibits primary neurogenesis. It plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 binds and activates Notch-1 or another Notch receptor. Defects in DLL3 are the cause of spondylocostal dysostosis type 1 (SCDO1).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-325)
Fournisseur:
ProSci Inc.
Description:
Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-334)
Fournisseur:
ProSci Inc.
Description:
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. The membrane receptor FNDC5 can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-896)
Fournisseur:
ProSci Inc.
Description:
Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-RP3065)
Fournisseur:
ProSci Inc.
Description:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3186)
Fournisseur:
ProSci Inc.
Description:
Peflin has a longer N-terminal hydrophobic domain than any other member of the family, and it contains nine nonapeptide (A/PPGGPYGGP) repeats. Western blot analysis demonstrated that peflin (30 kDa) was expressed in various nonadherent and adherent cultured human cell lines, including Jurkat, HL60, HeLa, and HT1080. Peflin may play basic roles in Ca(2+) signaling irrespective of cell types.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-239)
Fournisseur:
ProSci Inc.
Description:
OX40L [CD252; CD134L] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its ligand OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. MultimericOX40L is a high activity construct in which two trimeric OX40L ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively activates T cell proliferation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6935P)
Fournisseur:
ProSci Inc.
Description:
ZF21 peptide is used for blocking the activity of ZF21 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5659P)
Fournisseur:
ProSci Inc.
Description:
LYRM1 peptide is used for blocking the activity of LYRM1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6381P)
Fournisseur:
ProSci Inc.
Description:
MEIG1 peptide is used for blocking the activity of MEIG1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5587P)
Fournisseur:
ProSci Inc.
Description:
CHORDC1 peptide is used for blocking the activity of CHORDC1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-243)
Fournisseur:
ProSci Inc.
Description:
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumour cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasma blasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the NH2 terminus of APRIL is required for binding to negatively charged sulphated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumour cells as well as primary lymphoid cells.
UOM:
1 * 1 EA
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