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Protéines et Peptides
Numéro de catalogue:
(PRSI4537P)
Fournisseur:
ProSci Inc.
Description:
NIPSNAP peptide is used for blocking the activity of NIPSNAP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3419P)
Fournisseur:
ProSci Inc.
Description:
Anthrax peptide is used for blocking the activity of Anthrax edema factor antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3429P)
Fournisseur:
ProSci Inc.
Description:
West Nile virus peptide is used for blocking the activity of West Nile Virus Matrix Protein antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3435P)
Fournisseur:
ProSci Inc.
Description:
West Nile virus peptide is used for blocking the activity of West Nile Virus Core Protein antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-759)
Fournisseur:
ProSci Inc.
Description:
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits factors Xa and XIa of the coagulation cascade in the presence of protein Z, calcium, and phospholipid. Mutations in SERPINA10 are associated with venous thrombosis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-763)
Fournisseur:
ProSci Inc.
Description:
Transforming Growth Factor beta -1 (TGF beta -1) is a secreted protein which belongs to the TGF- beta family. TGF beta -1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGF beta -1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGF beta -1 peptide. TGF beta -1 may also form heterodimers with other TGF beta family members. It has been found that TGF beta -1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-491)
Fournisseur:
ProSci Inc.
Description:
Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. It binds both secreted and transmembrane proteins that transduce its function. It binds human neutrophil defensins, modulating influenza anti-viral defense. It binds MD-2/LY96, a secreted protein that cooperates with Toll-like receptors (TLRs) in the response of macrophages to bacterial lipopolysaccharides (LPS) or cell wall components. It also binds macrophage CD14 and TLRs directly, blocking binding of LPS and down-regulating TNF- alpha secretion. SP-D binding of both SIRP alpha and the calreticulin/CD91 complex on macrophages allows for a graded response to environmental challenge.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3187P)
Fournisseur:
ProSci Inc.
Description:
CARD8 peptide is used for blocking the activity of CARD8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-224)
Fournisseur:
ProSci Inc.
Description:
ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3191P)
Fournisseur:
ProSci Inc.
Description:
CARMA2 peptide is used for blocking the activity of CARMA2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-RP3212)
Fournisseur:
ProSci Inc.
Description:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 α subunits and 2 rings are composed of 7 β subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-RP3215)
Fournisseur:
ProSci Inc.
Description:
The covalent attachment of prenyl lipids, such as farnesyl or geranylgeranyl groups, by specific transferases is indispensable for the cellular sorting of many proteins. James et al. (1994) identified in hamster a farnesylated protein, called peroxisomal farnesylated protein or PxF, that localized to the outer surface of peroxisomes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3079)
Fournisseur:
ProSci Inc.
Description:
A carboxylic ester + H2O = an alcohol + a carboxylic anion. Homodimer. Cytoplasmic vesicles. There are two major electrophoretic isotypes. The sequence of the ESD*1 variant is shown. Similar to yeast HRE299.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-343)
Fournisseur:
ProSci Inc.
Description:
Lumican is a 40 kD secreted protein which belongs to the small leucine-rich repeat proteoglycans (SLRPs) and the class II subfamily. Human Lumican is synthesized as a 338 amino acid precursor then cut the 18 aa signal sequence. The mature Human Lumican contains 12 leucine-rich repeats (LRRs), 4 potential sites of N-linked glycosylation, and a C- terminal with two conserved cyst-eines. Lumican can be existed in extracellular matrix of human articular cartilage. Lumican participates in the maintenance of tissue homeostasis and regulates cellular functions in vivo, such as cell proliferation, adhesion, migration, and differentiation. The overexpression of lumican has been correlated to colorectal tumor, breast, neuroendocrine, and pancreatic cancers.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-313)
Fournisseur:
ProSci Inc.
Description:
ESM-1, short from Endothelial cell-specific molecule 1, is expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney. It is a secretory protein, and can be inducted by TNF and IL1B/interleukin-1beta, but not IL4/interleukin-4. This protein plays great roles in angiogenesis, sprouting, and may have potent implications in lung endothelial cell-leukocyte interactions.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-490)
Fournisseur:
ProSci Inc.
Description:
Interleukin-8 (IL-8) was originally discovered as a neutrophil chemotactic and activating factor and is a member of the alpha (CXC) subfamily of chemokines (including also platelet factor 4, GRO, IP-10, etc.). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes and various tumour cell lines, produce IL-8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS and viruses. IL-8 has a wide range of other proinflammatory effects. It is a potent chemoattractant for neutrophils and causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both in vivo and in vitro.
UOM:
1 * 1 EA
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