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Protéines et Peptides
Numéro de catalogue:
(PRSI90-307)
Fournisseur:
ProSci Inc.
Description:
Flagellin is the subunit protein which polymerises to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) or the intracellular NLRC4 protein. The Flagellin (TLR5 Mutant)(rec. ) cannot be detected by human and mouse TLR5. It has not been tested on NLRC4.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5193P)
Fournisseur:
ProSci Inc.
Description:
SCARB1 peptide is used for blocking the activity of SCARB1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-410)
Fournisseur:
ProSci Inc.
Description:
SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. However, SEMA4D is expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signalling. SEMA4D is involved in a number of fundamental biological processes such as promoting reorganisation of the actin cytoskeleton, the migration of cerebellar granule cells and of endothelial cells and signalling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signalling cascade. Not only these, it plays a role in axonal growth cone guidance in the developing central nervous system. Semaphorin-4D / SEMA4D may play a functional role in the immune system, as well as in the nervous system. It could induce B-cells to aggregate and improves their viability (in vitro). SEMA4D is involved in regulating dendrite and axon branching and morphogenesis and promoting interaction with PLXNB1 mediates activation of RHOA.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-409)
Fournisseur:
ProSci Inc.
Description:
SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement system to prevent spontaneous activation. SERPIN G1 may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. SERPIN G1 prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. SERPIN G1 is a very efficient physiological inhibitor of FXIIa, plasma kallikrein and fXIa, and could inhibit chymotrypsin and kallikrein. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases in the C1 complex of classical pathway of complement. Activation of the C1 complex is under control of the C1-inhibitor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-649)
Fournisseur:
ProSci Inc.
Description:
Transmembrane Protease Serine 11B (TMPRSS11B) is a single-pass type II membrane protein member of the peptidase S1 family. TMPRSS11B contains one peptidase S1 domain and one SEA domain. TMPRSS11B is a serine protease that may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-624)
Fournisseur:
ProSci Inc.
Description:
B18R, also known as B19R in the Copenhagen strain of Vaccinia, is a type I interferon (IFN)-binding protein encoded by the B18R open reading frame in the Western Reserve strain of vaccinia virus. B18R exists in two forms, soluble and membrane-bound form and has a broad species specificity. B18R has high affinity for human IFN-alpha and binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. Secreted B18R binds to uninfected and infected cells. B18R presents at the cell surface and protects cells from the antiviral state. It has shown that binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-504)
Fournisseur:
ProSci Inc.
Description:
Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumour mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumour antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumour-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumour effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumour vaccines.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-509)
Fournisseur:
ProSci Inc.
Description:
Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumours, leading to tumour rejection that is perforin dependent but IFN-gamma independent.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-500)
Fournisseur:
ProSci Inc.
Description:
Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-620)
Fournisseur:
ProSci Inc.
Description:
Human Follicle-stimulating hormone (FSH) is a member of glycoprotein hormones subunit beta family, which also includes LH, chorionic gonadotropin (CG) and thyroid-stimulating hormone (TSH). FSH and its family members are heterodimers consisting of non-covalently linked alpha- and beta -subunits. They share an identical alpha subunit, and beta -subunits vary. FSH has a unique beta -subunit (FSH beta ), which confers its specific biologic activity and is responsible for interaction with the FSH-receptor which belongs to a subfamily of GPCRs called leucine-rich-repeat-containing GPCRs (LGRs). FSH is secreted from the pituitary gland and regulates reproduction in mammals. FSH stimulates Sertoli cell proliferation in testes and supports spermatogenesis in males, and induces the maturation of ovarian follicles in females.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3553P)
Fournisseur:
ProSci Inc.
Description:
Adiponectin peptide is used for blocking the activity of the adiponectin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3531P)
Fournisseur:
ProSci Inc.
Description:
SARS envelope peptide is used for blocking the activity of the SARS envelope antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-341)
Fournisseur:
ProSci Inc.
Description:
PARP-2 [ARTD2] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signalling pathway leading to the reparation of DNA strand breaks.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-349)
Fournisseur:
ProSci Inc.
Description:
NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappaB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappaB p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3.
UOM:
1 * 2 µG
Numéro de catalogue:
(PRSI4797P)
Fournisseur:
ProSci Inc.
Description:
KINDLIN3 peptide is used for blocking the activity of ACVR1C antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-004)
Fournisseur:
ProSci Inc.
Description:
4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.
UOM:
1 * 1 EA
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