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Eiwitten en peptiden
Itemnummer:
(PRSI90-095)
Leverancier:
ProSci Inc.
Omschrijving:
FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6557P)
Leverancier:
ProSci Inc.
Omschrijving:
AFAP1 peptide is used for blocking the activity of AFAP1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6553P)
Leverancier:
ProSci Inc.
Omschrijving:
SPATA4 peptide is used for blocking the activity of SPATA4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6595P)
Leverancier:
ProSci Inc.
Omschrijving:
CD33 peptide is used for blocking the activity of CD33 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6593P)
Leverancier:
ProSci Inc.
Omschrijving:
MS4A6A peptide is used for blocking the activity of MS4A6A antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-521)
Leverancier:
ProSci Inc.
Omschrijving:
Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-004)
Leverancier:
ProSci Inc.
Omschrijving:
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis). GITRL is constitutively expressed and released as soluble form by solid tumours and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukaemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumours.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-511)
Leverancier:
ProSci Inc.
Omschrijving:
Myelin Oligodendrocyte Glycoprotein (MOG) is a transmembrane protein, which is expressed exclusively in the CNS. MOG contains a single Ig-domain exposed to the extracellular space which allows autoantibodies easy access. MOG protein has been identified as a crucial autoantigen for multiple sclerosis in humans. MOG is capable to produce a demyelinating multiple sclerosis-like disease in experimental animals,namely experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-506)
Leverancier:
ProSci Inc.
Omschrijving:
Apolipoprotein M is a secreted protein which belongs to the Lipocalin family. ApoM often presents in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL). The ApoM gene encoded protein is expressed in liver and kidney, secreted through the plasma membrane but remains membrane-bound. ApoM probably involved in lipid transport. ApoM can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. The expression of ApoM could be regulated by platelet activating factor (PAF), Transforming Growth Factors (TGF), Insulin-Like Growth factor (IGF) and Leptin.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3141P)
Leverancier:
ProSci Inc.
Omschrijving:
TLR4 peptide is used for blocking the activity of TLR4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-557)
Leverancier:
ProSci Inc.
Omschrijving:
Mannan-Binding Lectin Serine Protease 1 (MASP-1) belongs to the peptidase S1 family. MASP1 contains two CUB domains, one EGF-like domain, one peptidase S1 domain and two Sushi (CCP/SCR) domains. MASP1 is primarily expressed in liver. MASP1 involved in the lectin pathway of the complement, performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. MASP1 is synthesized as a zymogen and activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. MASP1 is not directly involved in complement activation but may act as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP2. MASP1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. MASP1 is inhibited by SERPING1 and A2M.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7353P)
Leverancier:
ProSci Inc.
Omschrijving:
17 amino acid peptide near the amino terminus of human UNG2.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-403)
Leverancier:
ProSci Inc.
Omschrijving:
CD99 is a type I transmembrane glycoprotein and the founding member of the CD99 family of molecules. The extracellular domain of CD99 contains no identifiable motifs, its cytoplasmic region, although short, does have signal transduction capability. Cells known to express CD99 include fibroblasts, neutrophils, T cells, double positive thymocytes, CD34+ stem cells, monocytes and endothelial cells. Two types of CD99 isoforms have been classified. Native human CD99 is referred to as the long, or type I isoform. The best studied type II isoform shows an Asp-Gly substitution for the C terminal 27 amino acids. The type I and II isoforms have distinctive signal transduction pathways (FAKsrc for type I PI3K plus srcERK1/2 for type II), and mediate clearly different biological outcomes. Homophilic interaction between CD99 on the neutrophil and CD99 on the endothelial cell regulates the transendothelial migration of neutrophils during inflammation. Human CD99 has 48% aa sequence identity to mouse CD99.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3451P)
Leverancier:
ProSci Inc.
Omschrijving:
Caspase-4 peptide is used for blocking the activity of caspase-4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-266)
Leverancier:
ProSci Inc.
Omschrijving:
MOB-Like Protein Phocein is a member of the MOB1/Phocein Family. MOB-Like Protein Phocein is associated with membranes and the Golgi stacks. It is present in the cytosol, where it behaves as a protein complex. It has been shown that MOB-Like Protein Phocein interacts with DNM1, EPS15 and Nucleoside Diphosphate Kinase. MOB-Like Protein Phocein is the major partner of Striatin Family members and may play a important role in membrane trafficking, specifically in membrane budding reactions.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-270)
Leverancier:
ProSci Inc.
Omschrijving:
Human Histone Chaperone ASF1A (ASF1A) belongs to the H3/H4 family of histone chaperone proteins. ASF1A is ubiquitously expressed in many cells and tissues, interacting with histones H3 and H4. ASF1A cooperates with Chromatin Assembly Factor 1 to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. In addition, ASF1A is necessary for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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